fluconazole vs isavuconazonium
PlainMeds reviewed this comparison against our methodology in August 2026. It places FDA and CMS record fields side by side, without recommending either medication.
Side-by-side comparison of fluconazole and isavuconazonium. Data from FDA drug databases (Orange Book, NDC Directory, recalls, shortages) covering 20,000+ approved drugs, plus CMS pricing; see our methodology.
Diflucan
Cresemba
Fluconazole is an antifungal medicine. It is used to treat infections caused by fungus.
Cresemba is an antifungal medicine. It is used to treat serious fungal infections in adults and children.
Fluconazole treats vaginal yeast infections. It also treats yeast infections in the mouth and esophagus. Fluconazole can also treat urinary tract infections, peritonitis, systemic Candida infections, and pneumonia. It can also treat cryptococcal meningitis. Fluconazole can also prevent candidiasis in patients undergoing bone marrow transplantation.
Cresemba treats invasive aspergillosis and invasive mucormycosis. These are serious infections caused by different types of fungi. Cresemba is available as an injection for those 1 year and older. Cresemba capsules are for those 6 years and older who weigh at least 35 pounds.
Fluconazole works by stopping the growth of fungi. It blocks the fungus from producing a substance it needs to grow. This helps to clear up the infection.
Cresemba belongs to a class of drugs called azole antifungals. It works by stopping the growth of the fungi. This helps your body fight off the infection.
- • Headache
- • Nausea
- • Abdominal pain
- • Nausea
- • Vomiting
- • Diarrhea
- • Headache
- • Changes in liver tests
- Pyrexia 4,121
- Nausea 3,697
- Diarrhoea 3,538
- Fatigue 3,151
- Pain 3,123
- Death 310
- Nausea 143
- Febrile Neutropenia 135
- Pyrexia 125
- Pneumonia 114
Coadministration of other drugs known to prolong the QT interval and which are metabolized via the enzyme CYP3A4 such as erythromycin, pimozide, and quinidine are contraindicated in patients receiving fluconazole.
Cresemba can cause serious liver problems. Your doctor will check your liver function before and during treatment. Cresemba can also cause allergic reactions. Tell your doctor right away if you have any signs of a reaction, like trouble breathing or skin rash. Cresemba can harm an unborn baby. Use birth control while taking this medicine.
Tell your doctor if you are pregnant or plan to become pregnant. Fluconazole may not be safe for your baby. Talk to your doctor about breastfeeding while taking fluconazole.
Cresemba can harm your unborn baby. Tell your doctor if you are pregnant or plan to become pregnant. Do not breastfeed while taking Cresemba.
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How to Read This fluconazole vs isavuconazonium Comparison
fluconazole is classified in the Azole Antifungal drug class, while isavuconazonium sits within the Azole Antifungal class. Because both drugs share the same classification, they are often considered interchangeable in theory, but clinical outcomes rarely track that cleanly. Both drugs are prescription-only, so a licensed provider must authorize use.
Adverse event totals above are pulled from the FDA's Adverse Event Reporting System (FAERS). For these top-ranked reactions alone, fluconazole has 17,630 submissions while isavuconazonium has 827. Those figures reflect cumulative reporting volume, not per-patient risk, so older, widely dispensed drugs typically look worse on count alone. No direct interaction between these two drugs is listed in our FDA-derived dataset, though co-prescription still warrants pharmacist review. Serious warnings, pregnancy guidance, and contraindications can differ even when indications overlap.
A table cannot represent individual circumstances. Data here is sourced from FDA Structured Product Labels (SPL) and FAERS, both of which update as manufacturers and clinicians submit new information. This registry does not provide medical, treatment, substitution, or medication-change directions for fluconazole or isavuconazonium.
Registry boundary: This comparison displays source-record fields and does not provide individualized medical direction.