ibuprofen vs voriconazole
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Side-by-side comparison of ibuprofen and voriconazole. Data from FDA drug databases (Orange Book, NDC Directory, recalls, shortages) covering 20,000+ approved drugs, plus CMS pricing; see our methodology.
minor Known Drug Interaction
ibuprofen and diclofenac (CYP2C9 Inhibition) Increased Frequent monitoring for adverse reactions and toxicity related to NSAIDs.
Advil, Motrin
Vfend
Ibuprofen is a drug that can reduce pain and fever. It belongs to a class of drugs called NSAIDs.
Voriconazole (Vfend) is an antifungal medicine. It is used to treat serious fungal infections in adults and children 2 years and older.
Ibuprofen can help with minor aches and pains. You can use it for headaches, toothaches, backaches, menstrual cramps, and muscle aches. It can also help with the common cold, minor arthritis pain, and fever.
This medicine treats several types of fungal infections. It is used for invasive aspergillosis, a lung infection. It also treats candidemia (a blood infection) and other Candida infections in the skin, abdomen, kidney, bladder, and wounds. Voriconazole can also treat esophageal candidiasis (a throat infection) and serious infections caused by Scedosporium and Fusarium fungi.
Ibuprofen works by reducing hormones that cause pain and swelling in the body. It blocks the production of prostaglandins. Prostaglandins contribute to inflammation and pain signals.
Voriconazole belongs to a class of drugs called azole antifungals. It works by stopping the growth of fungi. It does this by interfering with the production of the fungal cell membrane.
- • Nausea
- • Headache
- • Diarrhea
- • Vomiting
- • Dizziness
- • Visual disturbances
- • Fever
- • Nausea
- • Rash
- • Vomiting
- Pain 18,855
- Fatigue 17,866
- Nausea 17,352
- Headache 15,815
- Arthralgia 12,950
- Drug Interaction 2,315
- Death 1,460
- Pyrexia 1,411
- Pneumonia 1,321
- Condition Aggravated 1,093
NSAIDs like ibuprofen may increase the risk of serious cardiovascular thrombotic events, myocardial infarction, and stroke, which can be fatal. This risk may increase with duration of use. NSAIDs also increase the risk of serious gastrointestinal adverse events including bleeding, ulceration, and perforation of the stomach or intestines, which can be fatal.
Voriconazole can cause serious liver problems. Your doctor will check your liver function with blood tests before and during treatment. This medicine can also cause heart rhythm problems. Make sure your potassium, magnesium, and calcium levels are normal before starting. Voriconazole can also cause severe skin reactions and make you sensitive to sunlight. Avoid sunlight and wear protective clothing. This medicine can harm an unborn baby, so women who can get pregnant should use effective birth control.
Ask a doctor before using if you are pregnant or breastfeeding. NSAIDs like ibuprofen may cause harm to the fetus.
Voriconazole can cause harm to an unborn baby. If you are pregnant or could become pregnant, talk to your doctor. It is not known if voriconazole passes into breast milk. Talk to your doctor about the risks and benefits of breastfeeding while taking this medicine.
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How to Read This ibuprofen vs voriconazole Comparison
ibuprofen is classified in the Nonsteroidal Anti-Inflammatory Drug (NSAID) drug class, while voriconazole sits within the Azole Antifungal class. Drugs from different classes work through distinct mechanisms, so a head-to-head comparison illustrates trade-offs rather than equivalence. Both drugs are split between OTC and prescription status, which affects access and supervision.
Adverse event totals above are pulled from the FDA's Adverse Event Reporting System (FAERS). For these top-ranked reactions alone, ibuprofen has 82,838 submissions while voriconazole has 7,600. Those figures reflect cumulative reporting volume, not per-patient risk, so older, widely dispensed drugs typically look worse on count alone. These two drugs have a known minor interaction flagged in FDA labeling, attributed to voriconazole blocks the enzyme that breaks down ibuprofen, which can lead to higher levels of the painkiller in your body.. Serious warnings, pregnancy guidance, and contraindications can differ even when indications overlap.
A table cannot represent individual circumstances. Data here is sourced from FDA Structured Product Labels (SPL) and FAERS, both of which update as manufacturers and clinicians submit new information. This registry does not provide medical, treatment, substitution, or medication-change directions for ibuprofen or voriconazole.
Registry boundary: This comparison displays source-record fields and does not provide individualized medical direction.