What the FDA labels say about taking them together
Fluconazole and voriconazole
Fluconazole's FDA label (Fluconazole) of April 2, 2026 names voriconazole in its drug interactions section, and voriconazole's label names fluconazole too. The fluconazole label: “Voriconazole Avoid concomitant administration of voriconazole and fluconazole.”
Check it at the source: the fluconazole FDA label on DailyMed (effective April 7, 2026, Zydus Pharmaceuticals (USA) Inc.); the voriconazole FDA label on DailyMed (effective February 26, 2026, Roerig).
What does the fluconazole label say about voriconazole?
Fluconazole label (Mylan Pharmaceuticals Inc., April 2, 2026), drug interactionsVoriconazole Avoid concomitant administration of voriconazole and fluconazole.
Source: FDA drug label (Fluconazole, NDA020090), Mylan Pharmaceuticals Inc., effective April 2, 2026 (SPL set 737e0fac-a2d2-4053-a0d7-edbfb6248f69), via openFDA
Source: FDA drug label (fluconazole), Zydus Pharmaceuticals (USA) Inc., effective April 7, 2026 (SPL set d1364455-1537-46d4-b093-38cca3be778f), via openFDA; the full label on DailyMed
What does the voriconazole label say about fluconazole?
Voriconazole label, drug interactionsFluconazole (CYP2C9, CYP2C19 and CYP3A4 Inhibition) Significantly Increased Avoid concomitant administration of voriconazole and fluconazole.
Voriconazole label (Xellia Pharmaceuticals USA LLC, January 11, 2023), drug interactionsDrug/Drug Class (Mechanism of Interaction by the Drug): Fluconazole (CYP2C9, CYP2C19 and CYP3A4 Inhibition); Voriconazole Plasma Exposure (C max and AUC τ after 200 mg every 12 hours): Significantly Increased; Recommendations for Voriconazole Dosage Adjustment/Comments: Avoid concomitant administration of voriconazole and fluconazole. Monitoring for adverse reactions and toxicity related to voriconazole is started within 24 hours after the last dose of fluconazole
Source: FDA drug label (Voriconazole, NDA208562), Xellia Pharmaceuticals USA LLC, effective January 11, 2023 (SPL set 9ec6eda2-2f15-423b-9ec6-819379a426e1), via openFDA
Source: FDA drug label (VFEND), NDA021630 (Pf Prism Cv), as published by Roerig, effective February 26, 2026 (SPL set ce3ef5cf-3087-4d92-9d94-9eb8287228db), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Fluconazole | Voriconazole | |
|---|---|---|
| Labeled for | Fungal infections, Urinary tract infections | Fungal infections |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $0.380 per tablet 200 mg tablet | $1.88 per tablet 200 mg tablet |
| Shortage now | No current entry | A presentation being discontinued |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once