Two medicines, side by side
Fexofenadine vs cetirizine
Fexofenadine and cetirizine are both labeled for allergies. Drugs@FDA records approvals of fexofenadine since 1996 and of cetirizine since 1995. Pharmacies paid $0.230 per fexofenadine HCl 180 mg tablet and $0.0613 per cetirizine HCl 10 mg tablet (NADAC, October 7, 2026); the strengths differ, so the two prices are not like for like. Cetirizine's other strengths are brand-only: $7.35 per unit (Zerviate 0.24% eye drop).
Check it at the source: the fexofenadine FDA label on DailyMed (effective June 15, 2026); the cetirizine FDA label on DailyMed (effective August 7, 2026).
Highlights of the fexofenadine record
Fexofenadine (Allegra) · label of June 15, 2026
Used for
From the label: indications(S) temporarily relieves these symptoms due to hay fever or other upper respiratory allergies: runny nose itchy, water eyes sneezing itching of the nose or throat
On the market
- Earliest approval on file
- July 25, 1996
- Generic labelers
- 101 labelers
- Pharmacy cost
- $0.230 per tablet
Supply and safety
- Shortage
- No current entry
- Recalls
- 21
Highlights of the cetirizine record
Cetirizine (All) · label of August 7, 2026
Used for
From the label: indicationstemporarily relieves these symptoms due to hay fever or other upper respiratory allergies: • runny nose, • sneezing, • itchy, watery eyes, • itching of the nose or throat
On the market
- Earliest approval on file
- December 8, 1995
- Generic labelers
- 149 labelers
- Pharmacy cost
- $0.0613 per tablet
Supply and safety
- Shortage
- No current entry
- Recalls
- 19
Source: FDA drug labels via openFDA (Fexofenadine label of June 15, 2026, Cetirizine label of August 7, 2026); NDC Directory, Drugs@FDA, NADAC, FDA shortages and recalls (October 8, 2026)
How do fexofenadine and cetirizine differ on the record?
Both are in FDA's class histamine-1 receptor antagonists.
Generics: fexofenadine since 2005; cetirizine since 2007 (Drugs@FDA).
| Fexofenadine | Cetirizine | |
|---|---|---|
| Labeled for | Allergies | Allergies |
| Pharmacologic class | Histamine-1 Receptor Antagonist | Histamine-1 Receptor Antagonist |
| How it works (label) | n/a | n/a |
| Half-life (label) | n/a | n/a |
| Earliest approval on file (Drugs@FDA) | July 25, 1996 | December 8, 1995 |
| First generic approved | July 13, 2005 | December 27, 2007 |
| Generic labelers (NDC) | 101 labelers | 149 labelers |
| Pharmacy cost (NADAC, each one's most listed form; strengths differ) | $0.230 per tablet (Fexofenadine HCl 180 mg tablet) | $0.0613 per tablet (Cetirizine HCl 10 mg tablet) |
| 12-month price change | -13% | -11% |
| Boxed warning | No | No |
| Shortage now | No current entry | No current entry |
| Recalls recorded | 21 | 19 |
| FAERS reports (a report is not proof of cause; counts follow how widely a medicine is used) | 40,772 | 171,713 |
| DEA schedule | none | none |
Source: Drugs@FDA, FDA NDC Directory, CMS NADAC of October 7, 2026, FDA shortages and recalls, FAERS via openFDA (FDA files October 8, 2026)
What next?
- Alternatives to fexofenadine
- every medicine labeled for the same conditions