dronedarone vs voriconazole
Side-by-side comparison of dronedarone and voriconazole. Data from FDA drug databases (Orange Book, NDC Directory, recalls, shortages) covering 20,000+ approved drugs, plus CMS pricing; see our methodology.
major Known Drug Interaction
7.2 Effects of Other Drugs on Dronedarone Ketoconazole and Other Potent CYP3A Inhibitors Concomitant use of ketoconazole as well as other potent CYP3A inhibitors such as itraconazole, voriconazole, ritonavir, clarithromycin, and nefazodone is contraindicated because exposure to dronedarone is significantly increased [see Contraindications (4) , Clinical Pharmacology (12.3) ] .
Recommendation: This drug combination must be avoided. Your doctor will need to adjust your treatment plan.
Multaq
Vfend
Multaq is a medicine that helps lower the risk of needing to stay in the hospital for atrial fibrillation (AFib). It is for people who have a history of AFib and are currently in normal heart rhythm.
Voriconazole (Vfend) is an antifungal medicine. It is used to treat serious fungal infections in adults and children 2 years and older.
Multaq is used to lower the risk of hospitalization if you have atrial fibrillation (AFib). AFib is an irregular heartbeat. This medicine is for people who used to have AFib, but are now in a normal heart rhythm.
This medicine treats several types of fungal infections. It is used for invasive aspergillosis, a lung infection. It also treats candidemia (a blood infection) and other Candida infections in the skin, abdomen, kidney, bladder, and wounds. Voriconazole can also treat esophageal candidiasis (a throat infection) and serious infections caused by Scedosporium and Fusarium fungi.
Multaq is an antiarrhythmic drug. It works by changing the electrical signals in the heart. This helps to keep your heart in a normal rhythm and prevent AFib from returning.
Voriconazole belongs to a class of drugs called azole antifungals. It works by stopping the growth of fungi. It does this by interfering with the production of the fungal cell membrane.
- • Diarrhea
- • Nausea
- • Abdominal pain
- • Vomiting
- • Feeling weak or tired
- • Visual disturbances
- • Fever
- • Nausea
- • Rash
- • Vomiting
- Irregular heartbeat 1,418
- Shortness of breath 834
- Tiredness 614
- Diarrhea 477
- Nausea 471
- The medicine is interacting with another medicine 2,315
- Death 1,460
- Fever 1,411
- Lung infection 1,322
- The condition is getting worse 1,093
Multaq can increase the risk of death, stroke, and heart failure in patients with severe heart failure or permanent AFib. You should not take this medicine if you have severe heart failure that recently required hospitalization or if you have permanent AFib and will not be converted to a normal heart rhythm.
Voriconazole can cause serious liver problems. Your doctor will check your liver function with blood tests before and during treatment. This medicine can also cause heart rhythm problems. Make sure your potassium, magnesium, and calcium levels are normal before starting. Voriconazole can also cause severe skin reactions and make you sensitive to sunlight. Avoid sunlight and wear protective clothing. This medicine can harm an unborn baby, so women who can get pregnant should use effective birth control.
Multaq can harm an unborn baby. If you are a woman who could become pregnant, use effective birth control while taking Multaq. Do not breastfeed while taking Multaq and for 5 days after your last dose.
Voriconazole can cause harm to an unborn baby. If you are pregnant or could become pregnant, talk to your doctor. It is not known if voriconazole passes into breast milk. Talk to your doctor about the risks and benefits of breastfeeding while taking this medicine.
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How to Read This dronedarone vs voriconazole Comparison
dronedarone is classified in the Class III Antiarrhythmic drug class, while voriconazole sits within the Azole Antifungal class. Drugs from different classes work through distinct mechanisms, so a head-to-head comparison illustrates trade-offs rather than equivalence. Both drugs are prescription-only, so a licensed provider must authorize use.
Adverse event totals above are pulled from the FDA's Adverse Event Reporting System (FAERS). For these top-ranked reactions alone, dronedarone has 3,814 submissions while voriconazole has 7,601. Those figures reflect cumulative reporting volume, not per-patient risk, so older, widely dispensed drugs typically look worse on count alone. These two drugs have a known major interaction flagged in FDA labeling, attributed to voriconazole interferes with the way your body breaks down dronedarone. this results in much higher levels of dronedarone, which can be unsafe.. Serious warnings, pregnancy guidance, and contraindications can differ even when indications overlap.
A table cannot substitute for clinical judgment. Effectiveness, tolerability, drug-drug interactions with your other medications, kidney and liver function, pregnancy status, insurance formulary, and price all feed into a decision that only a licensed prescriber can make responsibly. Data here is sourced from FDA Structured Product Labels (SPL) and FAERS, both of which update as manufacturers and clinicians submit new information. This page is for educational purposes only, is not medical advice, and should not be used to self-switch between dronedarone and voriconazole - always consult your physician or pharmacist first.
Important: This comparison is for informational purposes only. Drug effects vary between individuals. Always consult your doctor or pharmacist for personalized medical advice.