dapagliflozin vs lithium
PlainMeds reviewed this comparison against our methodology in August 2026. It places FDA and CMS record fields side by side, without recommending either medication.
Side-by-side comparison of dapagliflozin and lithium. Data from FDA drug databases (Orange Book, NDC Directory, recalls, shortages) covering 20,000+ approved drugs, plus CMS pricing; see our methodology.
minor Known Drug Interaction
Lithium Clinical Impact Concomitant use of an SGLT2 inhibitor with lithium may decrease serum lithium concentrations. Intervention Monitor serum lithium concentration more frequently during FARXIGA initiation and dosage changes.
Farxiga
Lithobid, Eskalith
Dapagliflozin (Farxiga) helps lower blood sugar in adults with type 2 diabetes. It also helps adults with heart failure or chronic kidney disease.
Lithium is a mood stabilizer medicine. It helps to balance mood swings.
This medicine can help adults with chronic kidney disease by reducing the risk of kidney problems, heart problems, and needing to go to the hospital for heart failure. It can also help adults with heart failure by reducing the risk of heart problems and needing urgent care for heart failure. For adults with type 2 diabetes, it can help lower the risk of needing to go to the hospital for heart failure.
Lithium is used to treat bipolar disorder. Bipolar disorder causes unusual shifts in mood, energy, activity levels, and concentration. Lithium helps to control the extreme highs (mania) and lows (depression) of this condition.
Dapagliflozin is a type of medicine called an SGLT2 inhibitor. It works in the kidneys to remove extra sugar from your body through your urine. This helps to lower your blood sugar levels.
Lithium affects the flow of sodium in nerve and muscle cells in the body. This helps to stabilize your mood. It may also affect other chemical messenger systems in the brain.
- • Yeast infections of the vagina
- • Common cold
- • Urinary tract infections
- • Tremor (shaking)
- • Nausea
- • Increased weight
- • Fatigue (feeling tired)
- • Vomiting
- Death 7,017
- Fatigue 2,250
- Nausea 2,218
- Dizziness 2,096
- Diarrhoea 2,074
- Toxicity To Various Agents 2,179
- Drug Interaction 1,526
- Tremor 1,462
- Nausea 1,344
- Weight Increased 1,153
Dapagliflozin can cause a serious condition called diabetic ketoacidosis (DKA), especially if you have type 1 diabetes. Symptoms include nausea, vomiting, stomach pain, and trouble breathing. If you have these symptoms, stop taking this medicine and get medical help right away. This medicine can also cause serious infections in the area between your genitals and anus. Get medical help right away if you have pain, tenderness, redness, or swelling in this area, along with a fever or feeling unwell.
Lithium levels in your blood need to be monitored closely by your doctor. Too much lithium can be toxic and cause serious side effects. Make sure to attend all scheduled blood tests.
This medicine may harm your unborn baby, especially during the second and third trimesters. It is not recommended while breastfeeding.
Lithium can harm your unborn baby. Talk to your doctor if you are pregnant or plan to become pregnant. Lithium can pass into breast milk and may harm a nursing infant. Talk to your doctor about the best way to feed your baby if you are taking lithium.
Also Compare, Nearby Drugs
Compare dapagliflozin with
How to Read This dapagliflozin vs lithium Comparison
dapagliflozin is classified in the SGLT2 Inhibitor drug class, while lithium sits within the Mood Stabilizer class. Drugs from different classes work through distinct mechanisms, so a head-to-head comparison illustrates trade-offs rather than equivalence. Both drugs are prescription-only, so a licensed provider must authorize use.
Adverse event totals above are pulled from the FDA's Adverse Event Reporting System (FAERS). For these top-ranked reactions alone, dapagliflozin has 15,655 submissions while lithium has 7,664. Those figures reflect cumulative reporting volume, not per-patient risk, so older, widely dispensed drugs typically look worse on count alone. These two drugs have a known minor interaction flagged in FDA labeling, attributed to taking this diabetes medicine can cause your body to get rid of lithium faster, lowering the amount in your blood.. Serious warnings, pregnancy guidance, and contraindications can differ even when indications overlap.
A table cannot represent individual circumstances. Data here is sourced from FDA Structured Product Labels (SPL) and FAERS, both of which update as manufacturers and clinicians submit new information. This registry does not provide medical, treatment, substitution, or medication-change directions for dapagliflozin or lithium.
Registry boundary: This comparison displays source-record fields and does not provide individualized medical direction.