FDA pharmacologic class
Estrogen Agonist/Antagonist
5 medicines are in FDA's class of estrogen agonist/antagonists: raloxifene (Evista), tamoxifen (Soltamox), clomiphene (Clomid), toremifene (Fareston) and ospemifene (Osphena); 1 combination product also contains one. 4 of the 6 are listed from generic labelers (FDA NDC Directory, October 8, 2026). The lowest pharmacy cost is raloxifene hcl 60 mg tablet at $0.223 per tablet (NADAC).
Which medicines are estrogen agonist/antagonist?
| Medicine | Brand names | Generic labelers (all forms) | Pharmacy cost | Boxed warning | Shortage | Recalls since 2012 |
|---|---|---|---|---|---|---|
| Raloxifene | Evista | 17 labelers | $0.223 per tablet 60 mg tablet | Yes | No current entry | 1 |
| Tamoxifen | Soltamox | 10 labelers | $0.277 per tablet 20 mg tablet | Yes | No current entry | 0 |
| Clomiphene | Clomid, Milophene | 11 labelers | $4.21 per tablet 50 mg tablet | No | No current entry | 2 |
| Toremifene | Fareston | 2 labelers | $19.60 per tablet 60 mg tablet | Yes | No current entry | 0 |
| Bazedoxifene and estrogens conjugated | Duavee | none listed | $6.48 per tablet 0.45-20 mg tablet | Yes | No current entry | 0 |
| Ospemifene | Osphena | none listed | $8.17 per tablet 60 mg tablet | Yes | No current entry | 0 |
Source: FDA Established Pharmacologic Class (NDC Directory, openFDA); CMS NADAC of October 7, 2026; FDA shortages and recalls (FDA files October 8, 2026)
What do pharmacies pay?
Each medicine's most widely listed form, per unit, in the NADAC survey: what pharmacies paid, not what a patient pays; strengths differ, so compare like with like.
Source: CMS National Average Drug Acquisition Cost (NADAC) survey, October 7, 2026: what retail pharmacies paid per unit; not a counter price