Medicines labeled for the same conditions
Alternatives to tolcapone
13 other medicines are given the same way (oral) and in the same FDA class as tolcapone or labeled mainly for the same use (parkinson's disease); 3 are in its class, catechol-o-methyltransferase inhibitors: carbidopa and entacapone and levodopa, entacapone and opicapone; the others include 2 nonergot dopamine agonists, 1 aromatic amino acid and 1 antihistamine (FDA labels read October 8, 2026). In the same class, the lowest pharmacy cost is $0.325 per entacapone 200 mg tablet (what pharmacies paid in the NADAC survey; strengths differ).
Which medicines are labeled for the same conditions as tolcapone?
Parkinson's disease lists all 19 medicines labeled for it, by any route. Each row shows the conditions both labels name. They are listed as public records, not as substitutes: whether one can replace another depends on the person and is a prescriber's decision.
| Medicine and FDA class | Shared indication | Generic labelers (oral) | Pharmacy cost | Boxed warning | Shortage |
|---|---|---|---|---|---|
| Tolcaponecatechol-o-methyltransferase inhibitor | this medicine | 1 labeler | n/a | Yes | No current entry |
| Carbidopa and entacapone and levodopaaromatic amino acid · same class | Parkinson's disease | 4 labelers | $0.695 per tablet 25-100-200 mg tablet | No | No current entry |
| Entacaponecatechol-o-methyltransferase inhibitor · same class | Parkinson's disease | 11 labelers | $0.325 per tablet 200 mg tablet | No | No current entry |
| Opicaponecatechol-o-methyltransferase inhibitor · same class | Parkinson's disease | none listed | $24.67 per capsule 25 mg capsule | No | No current entry |
| Ropinirolenonergot dopamine agonist | Parkinson's disease | 27 labelers | $0.046 per tablet 0.25 mg tablet | No | No current entry |
| Pramipexolenonergot dopamine agonist | Parkinson's disease | 22 labelers | $0.0452 per tablet 0.25 mg tablet | No | No current entry |
| Carbidopa and levodopaaromatic amino acid | Parkinson's disease | 33 labelers | $0.0759 per tablet 25-100 tablet | No | No current entry |
| Benztropineantihistamine | Parkinson's disease | 19 labelers | $0.0753 per tablet 1 mg tablet | No | A presentation being discontinued |
| Rasagilinemonoamine oxidase inhibitor | Parkinson's disease | 14 labelers | $0.521 per tablet 0.5 mg tablet | No | No current entry |
| Trihexyphenidyl | Parkinson's disease | 8 labelers | $0.0884 per tablet 2 mg tablet | No | No current entry |
| Selegilinemonoamine oxidase type b inhibitor | Parkinson's disease | 11 labelers | $0.756 per capsule 5 mg capsule | No | No current entry |
| Bromocriptineergot derivative | Parkinson's disease | 6 labelers | $1.61 per tablet 2.5 mg tablet | No | No current entry |
| Carbidopaaromatic amino acid decarboxylation inhibitor | Parkinson's disease | 7 labelers | $0.536 per tablet 25 mg tablet | No | No current entry |
| Istradefylline | Parkinson's disease | none listed | n/a | No | No current entry |
Source: FDA drug labels (indications) via openFDA; FDA NDC Directory; CMS NADAC of October 7, 2026; FDA Drug Shortage Database (FDA files October 8, 2026)
What do pharmacies pay for each?
The headline NADAC price per unit of each medicine's most widely listed form; strengths differ, so compare like with like on each record.
Source: CMS National Average Drug Acquisition Cost (NADAC) survey, October 7, 2026: what retail pharmacies paid per unit; not a counter price
What next?
- Tolcapone: the full record
- label, generics, price, shortages, recalls