Medicines labeled for the same conditions
Alternatives to orphenadrine
8 other medicines are given the same way (oral) and in the same FDA class as orphenadrine or labeled mainly for the same use (muscle spasms and spasticity); 5 are in its class, muscle relaxants: cyclobenzaprine, methocarbamol, metaxalone, carisoprodol and 1 more; the others include 1 gamma-aminobutyric acid-ergic agonist, 1 central alpha-2 adrenergic agonist and 1 skeletal muscle relaxant (FDA labels read October 8, 2026). In the same class, the lowest pharmacy cost is $0.0171 per cyclobenzaprine 10 mg tablet (what pharmacies paid in the NADAC survey; strengths differ).
Which medicines are labeled for the same conditions as orphenadrine?
Muscle spasms and spasticity lists all 12 medicines labeled for it, by any route. Each row shows the conditions both labels name. They are listed as public records, not as substitutes: whether one can replace another depends on the person and is a prescriber's decision.
| Medicine and FDA class | Shared indication | Generic labelers (oral) | Pharmacy cost | Boxed warning | Shortage |
|---|---|---|---|---|---|
| Orphenadrinemuscle relaxant | this medicine | 14 labelers | $0.454 per tablet 100 mg tablet | No | No current entry |
| Cyclobenzaprinemuscle relaxant · same class | Muscle spasms and spasticity | 60 labelers | $0.0171 per tablet 10 mg tablet | No | No current entry |
| Methocarbamolmuscle relaxant · same class | Muscle spasms and spasticity | 54 labelers | $0.0395 per tablet 500 mg tablet | No | No current entry |
| Metaxalonemuscle relaxant · same class | Muscle spasms and spasticity | 33 labelers | $0.452 per tablet 800 mg tablet | No | No current entry |
| Carisoprodolmuscle relaxant · same class | Muscle spasms and spasticity | 24 labelers | $0.0706 per tablet 350 mg tablet | No | No current entry |
| Chlorzoxazonemuscle relaxant · same class | Muscle spasms and spasticity | 19 labelers | $0.210 per tablet 500 mg tablet | No | No current entry |
| Baclofengamma-aminobutyric acid-ergic agonist | Muscle spasms and spasticity | 52 labelers | $0.032 per tablet 10 mg tablet | No | No current entry |
| Tizanidinecentral alpha-2 adrenergic agonist | Muscle spasms and spasticity | 51 labelers | $0.0331 per tablet 4 mg tablet | No | No current entry |
| Dantroleneskeletal muscle relaxant | Muscle spasms and spasticity | 7 labelers | $0.409 per capsule 25 mg capsule | Yes | No current entry |
Source: FDA drug labels (indications) via openFDA; FDA NDC Directory; CMS NADAC of October 7, 2026; FDA Drug Shortage Database (FDA files October 8, 2026)
What do pharmacies pay for each?
The headline NADAC price per unit of each medicine's most widely listed form; strengths differ, so compare like with like on each record.
Source: CMS National Average Drug Acquisition Cost (NADAC) survey, October 7, 2026: what retail pharmacies paid per unit; not a counter price
What next?
- Orphenadrine: the full record
- label, generics, price, shortages, recalls
- Orphenadrine vs cyclobenzaprine
- two records side by side
- Orphenadrine vs methocarbamol
- two records side by side
- Carisoprodol vs orphenadrine
- two records side by side
- Chlorzoxazone vs orphenadrine
- two records side by side