Alternatives to eszopiclone
FDA shortage status is active for eszopiclone; 2 same-class SPL records are listed below for registry comparison only.
Brand: Lunesta
eszopiclone class peers while FDA lists an active shortage
eszopiclone (Lunesta) is on an FDA shortage listing while 2 other Non-Benzodiazepine Hypnotic (Z-Drug) SPL records remain in this registry peer set (class inventory 3). Labeled indication field for eszopiclone: Eszopiclone is used to treat insomnia, which means you have trouble falling asleep or staying asleep.
Top FAERS reaction fields for eszopiclone total 16,150 reports across 10 reactions, set beside zaleplon, zolpidem. Counts are exposure-weighted submissions, not per-patient risk.
About eszopiclone
Eszopiclone (Lunesta) is a medicine that helps you fall asleep and stay asleep. It is used to treat insomnia.
Used for: Eszopiclone is used to treat insomnia, which means you have trouble falling asleep or staying asleep. It can help you fall asleep faster and stay asleep longer. Studies have shown it works for up to 6 months.
2 Non-Benzodiazepine Hypnotic (Z-Drug) peers (wide set)
zaleplon
RxSonata
Zaleplon is used to treat insomnia, which means you have trouble falling asleep. It can help you fall asleep faster for up to 30 days. However, it does not increase the total time you sleep or decrease the number of times you wake up during the night.
zolpidem
RxAmbien
Zolpidem is used to treat insomnia when you have trouble falling asleep. It can help you fall asleep faster. Studies have shown it can decrease the time it takes to fall asleep for up to 35 days.
eszopiclone vs zaleplon & zolpidem · FAERS reaction fields
FAERS top-reaction field "Nausea" shows the widest count spread between eszopiclone and zaleplon, zolpidem in this extract (7,002-report gap on that field). Counts are exposure-weighted submissions, not prevalence rates.
| Side Effect | eszopiclone | zaleplon | zolpidem |
|---|---|---|---|
| Insomnia | 3,888 | 80 | 6,249 |
| Dysgeusia | 3,854 | - | - |
| Nausea | 1,382 | 111 | 8,384 |
| Middle Insomnia | 1,213 | - | - |
| Fatigue | 1,185 | 69 | 8,143 |
| Headache | 1,168 | 79 | 6,222 |
| Somnolence | 881 | 46 | 3,669 |
| Dizziness | 870 | 58 | 5,197 |
"-" means no reports for that reaction. Report counts reflect total FAERS submissions, not prevalence rates.
eszopiclone shortage vs Non-Benzodiazepine Hypnotic (Z-Drug) peer index
Shortage status
FDA shortage listing is active for eszopiclone (status: To Be Discontinued). Peer rows remain a registry index, not a switch guide.
Frequently Asked Questions
Does FDA list a shortage for eszopiclone while peers remain indexed? ▼
Registry note: Shortage listings and peer indexes are for registry orientation only. This information is for educational purposes only and is not a substitute for professional medical advice. Do not stop or change your medication without talking to your doctor or pharmacist.
Field note for eszopiclone: see also the generic vs brand label guide when reading Lunesta SPL strings.
Read our methodology - how this data is sourced, computed, and verified.