Medicines labeled for the same conditions
Alternatives to carbidopa and entacapone and levodopa
10 other medicines are given the same way (oral) and in the same FDA class as carbidopa and entacapone and levodopa or labeled mainly for the same use (parkinson's disease); 2 are in its class, aromatic amino acids: tolcapone and opicapone; the others include 2 nonergot dopamine agonists, 1 antihistamine and 1 monoamine oxidase inhibitor (FDA labels read October 8, 2026). In the same class, the lowest pharmacy cost is $24.67 per Ongentys 25 mg capsule (what pharmacies paid in the NADAC survey; strengths differ).
Which medicines are labeled for the same conditions as carbidopa and entacapone and levodopa?
Parkinson's disease lists all 19 medicines labeled for it, by any route. Each row shows the conditions both labels name. They are listed as public records, not as substitutes: whether one can replace another depends on the person and is a prescriber's decision.
| Medicine and FDA class | Shared indication | Generic labelers (oral) | Pharmacy cost | Boxed warning | Shortage |
|---|---|---|---|---|---|
| Carbidopa and entacapone and levodopaaromatic amino acid | this medicine | 4 labelers | $0.695 per tablet 25-100-200 mg tablet | No | No current entry |
| Tolcaponecatechol-o-methyltransferase inhibitor · same class | Parkinson's disease | 1 labeler | n/a | Yes | No current entry |
| Opicaponecatechol-o-methyltransferase inhibitor · same class | Parkinson's disease | none listed | $24.67 per capsule 25 mg capsule | No | No current entry |
| Ropinirolenonergot dopamine agonist | Parkinson's disease | 27 labelers | $0.046 per tablet 0.25 mg tablet | No | No current entry |
| Pramipexolenonergot dopamine agonist | Parkinson's disease | 22 labelers | $0.0452 per tablet 0.25 mg tablet | No | No current entry |
| Benztropineantihistamine | Parkinson's disease | 19 labelers | $0.0753 per tablet 1 mg tablet | No | A presentation being discontinued |
| Rasagilinemonoamine oxidase inhibitor | Parkinson's disease | 14 labelers | $0.521 per tablet 0.5 mg tablet | No | No current entry |
| Trihexyphenidyl | Parkinson's disease | 8 labelers | $0.0884 per tablet 2 mg tablet | No | No current entry |
| Selegilinemonoamine oxidase type b inhibitor | Parkinson's disease | 11 labelers | $0.756 per capsule 5 mg capsule | No | No current entry |
| Bromocriptineergot derivative | Parkinson's disease | 6 labelers | $1.61 per tablet 2.5 mg tablet | No | No current entry |
| Istradefylline | Parkinson's disease | none listed | n/a | No | No current entry |
Source: FDA drug labels (indications) via openFDA; FDA NDC Directory; CMS NADAC of October 7, 2026; FDA Drug Shortage Database (FDA files October 8, 2026)
What do pharmacies pay for each?
The headline NADAC price per unit of each medicine's most widely listed form; strengths differ, so compare like with like on each record.
Source: CMS National Average Drug Acquisition Cost (NADAC) survey, October 7, 2026: what retail pharmacies paid per unit; not a counter price
What next?
- Carbidopa and entacapone and levodopa: the full record
- label, generics, price, shortages, recalls