Medicines labeled for the same conditions
Alternatives to acetaminophen and ibuprofen
33 other medicines are given the same way (oral) and in the same FDA class as acetaminophen and ibuprofen or labeled mainly for the same use (pain); 13 are in its class, nonsteroidal anti-inflammatory drugs: naproxen, celecoxib, diclofenac, meloxicam and 9 more; the others include 11 opioid agonists, 1 cholinergic muscarinic antagonist and 1 partial opioid agonist/antagonist (FDA labels read October 8, 2026). In the same class, the lowest pharmacy cost is $0.0166 per meloxicam 7.5 mg tablet (what pharmacies paid in the NADAC survey; strengths differ).
Which medicines are labeled for the same conditions as acetaminophen and ibuprofen?
The first 24 of the 33, the same class first. Pain lists all 80 medicines labeled for it, by any route. Each row shows the conditions both labels name. They are listed as public records, not as substitutes: whether one can replace another depends on the person and is a prescriber's decision.
| Medicine and FDA class | Shared indication | Generic labelers (oral) | Pharmacy cost | Boxed warning | Shortage |
|---|---|---|---|---|---|
| Acetaminophen and ibuprofennonsteroidal anti-inflammatory drug | this medicine | 51 labelers | $0.107 per unit 250-125 mg | Yes | No current entry |
| Naproxennonsteroidal anti-inflammatory drug · same class | Pain | 146 labelers | $0.0565 per tablet 500 mg tablet | Yes | No current entry |
| Celecoxibnonsteroidal anti-inflammatory drug · same class | Pain | 65 labelers | $0.0762 per capsule 200 mg capsule | Yes | No current entry |
| Diclofenacnonsteroidal anti-inflammatory drug · same class | Pain | 67 labelers | $0.0619 per tablet 75 mg tablet | Yes | A presentation being discontinued |
| Meloxicamnonsteroidal anti-inflammatory drug · same class | Pain | 43 labelers | $0.0166 per tablet 7.5 mg tablet | Yes | No current entry |
| Etodolacnonsteroidal anti-inflammatory drug · same class | Pain | 30 labelers | $0.262 per tablet 400 mg tablet | Yes | No current entry |
| Ketorolaccyclooxygenase inhibitor · same class | Pain | 33 labelers | $0.164 per tablet 10 mg tablet | Yes | In shortage |
| Fenoprofennonsteroidal anti-inflammatory drug · same class | Pain | 6 labelers | n/a | Yes | No current entry |
| Diflunisalnonsteroidal anti-inflammatory drug · same class | Pain | 6 labelers | $1.06 per tablet 500 mg tablet | Yes | No current entry |
| Ketoprofennonsteroidal anti-inflammatory drug · same class | Pain | 5 labelers | $6.46 per capsule 200 mg capsule | Yes | No current entry |
| Mefenamic acidnonsteroidal anti-inflammatory drug · same class | Pain | 6 labelers | $0.948 per capsule 250 mg capsule | Yes | No current entry |
| Aspirin and caffeine and orphenadrinemuscle relaxant · same class | Pain | 3 labelers | n/a | No | No current entry |
| Aspirin, butalbital, caffeine and codeinebarbiturate · same class | Pain | 4 labelers | $1.00 per capsule Ascomp with codeine capsule | Yes | No current entry |
| Aspirin and oxycodoneplatelet aggregation inhibitor · same class | Pain | 1 labeler | n/a | Yes | No current entry |
| Aspirin | Pain | none listed | $0.0142 per tablet 81 mg tablet | No | A presentation being discontinued |
| Oxycodoneopioid agonist | Pain | 34 labelers | $0.0884 per tablet 5 mg tablet | Yes | No current entry |
| Tramadolopioid agonist | Pain | 40 labelers | $0.0248 per tablet 50 mg tablet | Yes | No current entry |
| Morphineopioid agonist | Pain | 17 labelers | $0.226 per tablet 15 mg tablet | Yes | In shortage |
| Phenazopyridine | Pain | none listed | $0.154 per tablet 100 mg tablet | No | No current entry |
| Phenol | Pain | none listed | $0.0124 per mL 1.4% spray | No | No current entry |
| Hydromorphoneopioid agonist | Pain | 11 labelers | $0.219 per tablet 4 mg tablet | Yes | In shortage |
| Methadoneopioid agonist | Pain | 17 labelers | $0.177 per tablet 10 mg tablet | Yes | No current entry |
| Benzocaine | Pain | none listed | n/a | No | No current entry |
| Oxymorphoneopioid agonist | Pain | 9 labelers | n/a | Yes | No current entry |
| Tapentadolopioid agonist | Pain | 4 labelers | $14.48 per tablet 100 mg tablet | Yes | No current entry |
Source: FDA drug labels (indications) via openFDA; FDA NDC Directory; CMS NADAC of October 7, 2026; FDA Drug Shortage Database (FDA files October 8, 2026)
What do pharmacies pay for each?
The headline NADAC price per unit of each medicine's most widely listed form; strengths differ, so compare like with like on each record.
Source: CMS National Average Drug Acquisition Cost (NADAC) survey, October 7, 2026: what retail pharmacies paid per unit; not a counter price
What next?
- Acetaminophen and ibuprofen: the full record
- label, generics, price, shortages, recalls