Medicines labeled for the same conditions

Alternatives to acetaminophen and aspirin and caffeine

18 other medicines are given the same way (oral) and in the same FDA class as acetaminophen and aspirin and caffeine or labeled mainly for the same use (cough and cold); 18 are in its class, platelet aggregation inhibitors: ibuprofen, naproxen, celecoxib, diclofenac and 14 more (FDA labels read October 8, 2026). In the same class, the lowest pharmacy cost is $0.0166 per meloxicam 7.5 mg tablet (what pharmacies paid in the NADAC survey; strengths differ).

Which medicines are labeled for the same conditions as acetaminophen and aspirin and caffeine?

Cough and cold lists all 31 medicines labeled for it, by any route. Each row shows the conditions both labels name. They are listed as public records, not as substitutes: whether one can replace another depends on the person and is a prescriber's decision.

Medicine and FDA class	Shared indication	Generic labelers (oral)	Pharmacy cost	Boxed warning	Shortage
Acetaminophen and aspirin and caffeineplatelet aggregation inhibitor	this medicine	39 labelers	$0.0648 per unit 250-250-65 mg cplt	No	No current entry
Ibuprofennonsteroidal anti-inflammatory drug · same class	Pain, Cough and cold, Fever	273 labelers	$0.0573 per tablet 800 mg tablet	Yes	No current entry
Naproxennonsteroidal anti-inflammatory drug · same class	Pain, Cough and cold, Fever	146 labelers	$0.0565 per tablet 500 mg tablet	Yes	No current entry
Celecoxibnonsteroidal anti-inflammatory drug · same class	Pain	65 labelers	$0.0762 per capsule 200 mg capsule	Yes	No current entry
Diclofenacnonsteroidal anti-inflammatory drug · same class	Pain	67 labelers	$0.0619 per tablet 75 mg tablet	Yes	A presentation being discontinued
Meloxicamnonsteroidal anti-inflammatory drug · same class	Pain	43 labelers	$0.0166 per tablet 7.5 mg tablet	Yes	No current entry
Etodolacnonsteroidal anti-inflammatory drug · same class	Pain	30 labelers	$0.262 per tablet 400 mg tablet	Yes	No current entry
Ketorolaccyclooxygenase inhibitor · same class	Pain	33 labelers	$0.164 per tablet 10 mg tablet	Yes	In shortage
Ibuprofen and pseudoephedrinealpha-adrenergic agonist · same class	Cough and cold	9 labelers	n/a	No	No current entry
Naproxen and pseudoephedrinealpha-adrenergic agonist · same class	Cough and cold	10 labelers	$0.244 per unit 220-120 mg	No	No current entry
Fenoprofennonsteroidal anti-inflammatory drug · same class	Pain	6 labelers	n/a	Yes	No current entry
Diflunisalnonsteroidal anti-inflammatory drug · same class	Pain	6 labelers	$1.06 per tablet 500 mg tablet	Yes	No current entry
Ketoprofennonsteroidal anti-inflammatory drug · same class	Pain	5 labelers	$6.46 per capsule 200 mg capsule	Yes	No current entry
Mefenamic acidnonsteroidal anti-inflammatory drug · same class	Pain	6 labelers	$0.948 per capsule 250 mg capsule	Yes	No current entry
Hydrocodone and ibuprofenopioid agonist · same class	Pain	2 labelers	$0.487 per unit 7.5-200	Yes	No current entry
Ibuprofen and phenylephrinealpha-1 adrenergic agonist · same class	Cough and cold	3 labelers	n/a	No	No current entry
Chlorpheniramine and ibuprofen and phenylephrinealpha-1 adrenergic agonist · same class	Cough and cold	none listed	n/a	No	No current entry
Chlorpheniramine and ibuprofen and pseudoephedrinehistamine-1 receptor antagonist · same class	Cough and cold	none listed	n/a	No	No current entry
Dextromethorphan and guaifenesin and naproxenexpectorant · same class	Fever	none listed	n/a	No	No current entry

Source: FDA drug labels (indications) via openFDA; FDA NDC Directory; CMS NADAC of October 7, 2026; FDA Drug Shortage Database (FDA files October 8, 2026)

What do pharmacies pay for each?

The headline NADAC price per unit of each medicine's most widely listed form; strengths differ, so compare like with like on each record.

Source: CMS National Average Drug Acquisition Cost (NADAC) survey, October 7, 2026: what retail pharmacies paid per unit; not a counter price

What next?

Acetaminophen and aspirin and caffeine: the full record: label, generics, price, shortages, recalls