FDA Drug Shortage Database
Methylprednisolone (Solu-Medrol) shortage
The FDA Drug Shortage Database lists 14 of 23 methylprednisolone presentations as limited or unavailable (updated October 2, 2026); the first entry was posted on December 15, 2021. 9 more presentations are on the list as available.
- Generic listed
- In shortage
Check it at the source: the FDA Drug Shortage Database.
Which strengths are short?
| Strength | Limited or unavailable now | Listed now, available | Resolved or discontinued |
|---|---|---|---|
| 20mg/1ml injection | 0 | 1 | 0 |
| 40mg/1ml injection | 9 | 4 | 0 |
| 80mg/1ml injection | 5 | 4 | 0 |
Which presentations are listed?
Limited or unavailable now (14)
| Presentation | Company | Status and dates | Availability and reason given |
|---|---|---|---|
| Depo-medrol, Injection, 40 mg/1 mL (NDC 0009-0280-03) | Pfizer Inc. | Current posted December 15, 2021, updated September 21, 2026 | Limited Availability; Other |
| Depo-medrol, Injection, 40 mg/1 mL (NDC 0009-3073-01) | Pfizer Inc. | Current posted December 15, 2021, updated September 21, 2026 | Limited Availability; Demand increase for the drug |
| Depo-medrol, Injection, 40 mg/1 mL (NDC 0009-3073-03) | Pfizer Inc. | Current posted December 15, 2021, updated September 21, 2026 | Limited Availability; Other |
| Depo-medrol, Injection, 40 mg/1 mL (NDC 0009-3073-22) | Pfizer Inc. | Current posted December 15, 2021, updated September 21, 2026 | Unavailable; Demand increase for the drug |
| Depo-medrol, Injection, 40 mg/1 mL (NDC 0009-3073-23) | Pfizer Inc. | Current posted December 15, 2021, updated September 21, 2026 | Unavailable; Other |
| Depo-medrol, Injection, 80 mg/1 mL (NDC 0009-3475-01) | Pfizer Inc. | Current posted December 15, 2021, updated September 21, 2026 | Limited Availability; Demand increase for the drug |
| Depo-medrol, Injection, 80 mg/1 mL (NDC 0009-3475-03) | Pfizer Inc. | Current posted December 15, 2021, updated September 21, 2026 | Limited Availability; Other |
| Methylprednisolone Acetate, Injection, 40 mg/1 mL (NDC 25021-820-05) | Sagent Pharmaceuticals | Current posted December 15, 2021, updated September 18, 2026 | Unavailable; Shortage of an active ingredient |
| Methylprednisolone Acetate, Injection, 40 mg/1 mL (NDC 25021-820-10) | Sagent Pharmaceuticals | Current posted December 15, 2021, updated September 18, 2026 | Unavailable; Shortage of an active ingredient |
| Methylprednisolone Acetate, Injection, 40 mg/1 mL (NDC 55150-313-01) | Eugia US LLC | Current posted December 15, 2021, updated October 2, 2026 | Unavailable; Demand increase for the drug |
| Methylprednisolone Acetate, Injection, 40 mg/1 mL (NDC 70121-1573-1) | Amneal Pharmaceuticals | Current posted December 15, 2021, updated June 17, 2026 | Limited Availability; Other |
| Methylprednisolone Acetate, Injection, 80 mg/1 mL (NDC 25021-821-05) | Sagent Pharmaceuticals | Current posted December 15, 2021, updated September 18, 2026 | Limited Availability; Shortage of an active ingredient |
| Methylprednisolone Acetate, Injection, 80 mg/1 mL (NDC 42023-240-01) | Par Health, USA LLC | Current posted June 16, 2022, updated October 2, 2026 | Unavailable; Other |
| Methylprednisolone Acetate, Injection, 80 mg/1 mL (NDC 55150-314-01) | Eugia US LLC | Current posted December 15, 2021, updated October 2, 2026 | Unavailable; Demand increase for the drug |
Listed now, available (9)
| Presentation | Company | Status and dates | Availability and reason given |
|---|---|---|---|
| Depo-medrol, Injection, 20 mg/1 mL (NDC 0009-0274-01) | Pfizer Inc. | Current posted December 15, 2021, updated September 21, 2026 | Available |
| Depo-medrol, Injection, 40 mg/1 mL (NDC 0009-0280-02) | Pfizer Inc. | Current posted December 15, 2021, updated September 21, 2026 | Available |
| Depo-medrol, Injection, 40 mg/1 mL (NDC 0009-0280-51) | Pfizer Inc. | Current posted December 15, 2021, updated September 21, 2026 | Available |
| Depo-medrol, Injection, 40 mg/1 mL (NDC 0009-0280-52) | Pfizer Inc. | Current posted December 15, 2021, updated September 21, 2026 | Available |
| Depo-medrol, Injection, 80 mg/1 mL (NDC 0009-0306-02) | Pfizer Inc. | Current posted December 15, 2021, updated September 21, 2026 | Available |
| Depo-medrol, Injection, 80 mg/1 mL (NDC 0009-0306-12) | Pfizer Inc. | Current posted December 15, 2021, updated September 21, 2026 | Available |
| Methylprednisolone Acetate, Injection, 40 mg/1 mL (NDC 70121-1573-5) | Amneal Pharmaceuticals | Current posted December 15, 2021, updated June 17, 2026 | Available |
| Methylprednisolone Acetate, Injection, 80 mg/1 mL (NDC 70121-1574-1) | Amneal Pharmaceuticals | Current posted December 15, 2021, updated June 17, 2026 | Available |
| Methylprednisolone Acetate, Injection, 80 mg/1 mL (NDC 70121-1574-5) | Amneal Pharmaceuticals | Current posted December 15, 2021, updated June 17, 2026 | Available |
Source: FDA Drug Shortage Database via openFDA, read October 8, 2026
Are medicines for the same conditions short too?
Medicines whose labels share an indication with this one, and their own shortage status; listed as records, not substitutes.
| Medicine | Shared indication | Shortage | Generic labelers | Pharmacy cost |
|---|---|---|---|---|
| Prednisone | Osteoarthritis, Allergies, Crohn's disease and ulcerative colitis, Herpes and shingles, Multiple sclerosis, Leukemia, lymphoma and myeloma, Anemia | No current entry | 45 labelers | $0.0643 per tablet 20 mg tablet |
| Dexamethasone | Osteoarthritis, Allergies, Crohn's disease and ulcerative colitis, Herpes and shingles, Leukemia, lymphoma and myeloma, Anemia | In shortage | 60 labelers | $0.193 per tablet 4 mg tablet |
| Hydrocortisone | Osteoarthritis, Allergies, Crohn's disease and ulcerative colitis, Herpes and shingles, Leukemia, lymphoma and myeloma | A presentation being discontinued | 49 labelers | $0.0613 per gram 1% cream |
| Prednisolone | Osteoarthritis, Allergies, Crohn's disease and ulcerative colitis, Herpes and shingles, Multiple sclerosis, Leukemia, lymphoma and myeloma, Anemia | No current entry | 25 labelers | $4.72 per mL 1% eye drop |
| Budesonide | Crohn's disease and ulcerative colitis | No current entry | 30 labelers | $0.498 per capsule 3 mg capsule |
| Cortisone | Osteoarthritis, Allergies, Crohn's disease and ulcerative colitis, Herpes and shingles, Leukemia, lymphoma and myeloma | No current entry | 1 labeler | n/a |
| Celecoxib | Osteoarthritis | No current entry | 63 labelers | $0.0762 per capsule 200 mg capsule |
| Meloxicam | Osteoarthritis | No current entry | 43 labelers | $0.0166 per tablet 7.5 mg tablet |
| Nabumetone | Osteoarthritis | No current entry | 28 labelers | $0.128 per tablet 500 mg tablet |
| Diclofenac and misoprostol | Osteoarthritis | No current entry | 10 labelers | $0.665 per tablet 50-0.2 mg tablet |
| Piroxicam | Osteoarthritis | No current entry | 10 labelers | $0.215 per capsule 20 mg capsule |
| Famotidine and ibuprofen | Osteoarthritis | No current entry | 16 labelers | $0.714 per unit 800-26.6 mg |
Source: FDA drug labels, FDA Drug Shortage Database, NDC Directory, CMS NADAC of October 7, 2026 (FDA files October 8, 2026)
What next?
- Every shortage now
- medicines by presentations in shortage