What the FDA labels say about taking them together
Thioridazine and zaleplon
Zaleplon's FDA label of May 8, 2024 names thioridazine in its drug interactions section; the thioridazine label PlainMeds reads does not name zaleplon. The zaleplon label: “Thioridazine Coadministration of single doses of zaleplon 20 mg and thioridazine 50 mg produced additive effects on decreased alertness and impaired psychomotor performance for 2 to 4 hours after administration.”
Check it at the source: the thioridazine FDA label on DailyMed (effective November 11, 2025, Mylan Institutional Inc.); the zaleplon FDA label on DailyMed (effective May 8, 2024, Aurobindo Pharma Limited).
What does the thioridazine label say about zaleplon?
Thioridazine's label (effective November 11, 2025) does not name zaleplon in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Thioridazine Hydrochloride), Mylan Institutional Inc., effective November 11, 2025 (SPL set 52fea941-0b47-41c1-b00d-f88150e8ab93), via openFDA; the full label on DailyMed
What does the zaleplon label say about thioridazine?
Zaleplon label, drug interactionsThioridazine Coadministration of single doses of zaleplon 20 mg and thioridazine 50 mg produced additive effects on decreased alertness and impaired psychomotor performance for 2 to 4 hours after administration.
Source: FDA drug label (ZALEPLON), Aurobindo Pharma Limited, effective May 8, 2024 (SPL set e092f3ca-bf44-4568-a72c-3fb2cf5b192b), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Thioridazine | Zaleplon | |
|---|---|---|
| Labeled for | n/a | Insomnia |
| Boxed warning | Yes | Yes |
| Pharmacy cost (NADAC) | $0.571 per tablet 25 mg tablet | $0.141 per capsule 10 mg capsule |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once