What the FDA labels say about taking them together
Warfarin and zileuton
Warfarin's FDA label of May 29, 2026 names zileuton in its drug interactions section, and zileuton's label names warfarin too. The zileuton label: “Monitor prothrombin time and adjust warfarin dose accordingly. Zileuton increases propranolol levels and beta-blocker activity. Monitor appropriately.”
Check it at the source: the warfarin FDA label on DailyMed (effective May 29, 2026, Amneal Pharmaceuticals LLC); the zileuton FDA label on DailyMed (effective July 29, 2022, Strides Pharma Science Limited).
What does the warfarin label say about zileuton?
Warfarin label, drug interactions… caffeine, cimetidine, ciprofloxacin, disulfiram, enoxacin, famotidine, fluvoxamine, methoxsalen, mexiletine, norfloxacin, oral contraceptives, phenylpropanolamine, propafenone, propranolol, terbinafine, thiabendazole, ticlopidine, verapamil, zileuton montelukast, moricizine, omeprazole, phenobarbital, phenytoin, cigarette smoking CYP3A4 alprazolam, amiodarone, amlodipine, amprenavir, aprepitant, atorvastatin, atazanavir, bicalutamide, cilostazol, cimetidine, ciprofloxacin, clarithromycin, conivaptan, cyclosporine, darunavir/ritonavir, diltiazem, erythromycin, fluconazole, fluoxetine, fluvoxamine, fosamprenavir, imatinib, indinavir, isoniazid, itraconazole, ketoconazole, lopinavir/ritonavir …
Source: FDA drug label (Warfarin Sodium), Amneal Pharmaceuticals LLC, effective May 29, 2026 (SPL set 558b7a0d-5490-4c1b-802e-3ab3f1efe760), via openFDA; the full label on DailyMed
What does the zileuton label say about warfarin?
Zileuton label, drug interactionsMonitor prothrombin time and adjust warfarin dose accordingly. (7.2) Zileuton increases propranolol levels and beta-blocker activity. Monitor appropriately.
Source: FDA drug label (Zileuton), Strides Pharma Science Limited, effective July 29, 2022 (SPL set a826d16f-df07-447b-b050-b9a02ea1f89e), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Warfarin | Zileuton | |
|---|---|---|
| Labeled for | Blood clots (DVT and PE), Atrial fibrillation | Asthma |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | $0.093 per tablet 2 mg tablet | $2.05 per tablet 600 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once