What the FDA labels say about taking them together
Tigecycline and warfarin
Tigecycline's FDA label of November 18, 2025 names warfarin in its drug interactions section, and warfarin's label names tigecycline too. The tigecycline label: “Suitable anticoagulation test should be monitored if TYGACIL is administered to patients receiving warfarin.”
Check it at the source: the tigecycline FDA label on DailyMed (effective November 18, 2025, Wyeth Pharmaceuticals LLC, a subsidiary of Pfizer Inc.); the warfarin FDA label on DailyMed (effective May 29, 2026, Amneal Pharmaceuticals LLC).
What does the tigecycline label say about warfarin?
Tigecycline label, drug interactionsSuitable anticoagulation test should be monitored if TYGACIL is administered to patients receiving warfarin.
Source: FDA drug label (Tigecycline, NDA211158), Amneal Pharmaceuticals LLC, effective December 17, 2024 (SPL set 8450bd15-2b06-4fc7-b302-9021312e3f0d), via openFDA
Source: FDA drug label (Tygacil), NDA021821 (Pf Prism Cv), as published by Wyeth Pharmaceuticals LLC, a subsidiary of Pfizer Inc., effective November 18, 2025 (SPL set fd826e47-1b77-4ffd-bb22-fda3379903b0), via openFDA; the full label on DailyMed
What does the warfarin label say about tigecycline?
Warfarin label, drug interactionsClosely monitor INR if a concomitant drug is a CYP2C9, 1A2, and/or 3A4 inhibitor or inducer. Examples of CYP450 Interactions with Warfarin Enzyme Inhibitors Inducers CYP2C9 amiodarone, capecitabine, cotrimoxazole, etravirine, fluconazole, fluvastatin, fluvoxamine, metronidazole, miconazole, oxandrolone, sulfinpyrazone, tigecycline, voriconazole, zafirlukast aprepitant, bosentan, carbamazepine, phenobarbital, rifampin CYP1A2 acyclovir, allopurinol, caffeine, cimetidine, ciprofloxacin, disulfiram, enoxacin, famotidine, fluvoxamine, methoxsalen, mexiletine, norfloxacin, oral contraceptives, phenylpropanolamine, propafenone, propranolol, terbinafine, thiabendazole, ticlopidine, verapamil …
Source: FDA drug label (Warfarin Sodium), Amneal Pharmaceuticals LLC, effective May 29, 2026 (SPL set 558b7a0d-5490-4c1b-802e-3ab3f1efe760), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Tigecycline | Warfarin | |
|---|---|---|
| Labeled for | Bacterial infections | Blood clots (DVT and PE), Atrial fibrillation |
| Boxed warning | Yes | Yes |
| Pharmacy cost (NADAC) | n/a | $0.093 per tablet 2 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once