What the FDA labels say about taking them together
Prasugrel and warfarin
Prasugrel's FDA label of February 11, 2025 names warfarin in its boxed warning section, and warfarin's label names prasugrel too. The prasugrel label: “Coadministration of Effient and warfarin increases the risk of bleeding.”
Check it at the source: the prasugrel FDA label on DailyMed (effective February 11, 2025, Panacea Biotec Limited); the warfarin FDA label on DailyMed (effective May 29, 2026, Amneal Pharmaceuticals LLC).
What does the prasugrel label say about warfarin?
Prasugrel label, boxed warningAdditional risk factors for bleeding include: body weight <60 kg; propensity to bleed; concomitant use of medications that increase the risk of bleeding (e.g., warfarin, heparin, fibrinolytic therapy, chronic use of non-steroidal anti-inflammatory drugs [NSAIDs]) [see Warnings and Precautions ( 5.1 )].
Prasugrel label, drug interactionsCoadministration of prasugrel tablets and warfarin increases the risk of bleeding [see Warnings and Precautions ( 5.1 ) and Clinical Pharmacology ( 12.3 )].
Source: FDA drug label (Effient, NDA022307), Cosette Pharmaceuticals, Inc., effective September 7, 2022 (SPL set 69ea2d58-5353-4222-b61f-cab976fa7e5e), via openFDA
Source: FDA drug label (PRASUGREL), Panacea Biotec Limited, effective February 11, 2025 (SPL set 944c195a-de24-a44c-8baa-84b624b5ddcb), via openFDA; the full label on DailyMed
What does the warfarin label say about prasugrel?
Warfarin label, drug interactionsDrug Class: Antiplatelet Agents; Specific Drugs: aspirin, cilostazol, clopidogrel, dipyridamole, prasugrel, ticlopidine
Source: FDA drug label (Warfarin Sodium), Amneal Pharmaceuticals LLC, effective May 29, 2026 (SPL set 558b7a0d-5490-4c1b-802e-3ab3f1efe760), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Prasugrel | Warfarin | |
|---|---|---|
| Labeled for | Heart attack and coronary artery disease, Angina | Blood clots (DVT and PE), Atrial fibrillation |
| Boxed warning | Yes | Yes |
| Pharmacy cost (NADAC) | $0.263 per tablet 10 mg tablet | $0.093 per tablet 2 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once