What the FDA labels say about taking them together
Bupropion and vortioxetine
Vortioxetine's FDA label of March 5, 2025 names bupropion in its drug interactions section; the bupropion labels PlainMeds reads (4) do not name vortioxetine.
Check it at the source: the bupropion FDA label on DailyMed (effective June 21, 2024); the vortioxetine FDA label on DailyMed (effective March 5, 2025, Takeda Pharmaceuticals America, Inc.).
What does the bupropion label say about vortioxetine?
Bupropion's label (effective June 21, 2024) and its 3 other brand-application labels do not name vortioxetine in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (BUPROPION HYDROCHLORIDE), Epic Pharma LLC, effective June 21, 2024 (SPL set 9fb44e96-6160-4a4a-90cb-91764c0dcd89), via openFDA; the full label on DailyMed
What does the vortioxetine label say about bupropion?
Vortioxetine label, drug interactionsExamples; bupropion, fluoxetine, paroxetine, quinidine
Source: FDA drug label (Trintellix), Takeda Pharmaceuticals America, Inc., effective March 5, 2025 (SPL set 1a5b68e2-14d0-419d-9ec6-1ca97145e838), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Bupropion | Vortioxetine | |
|---|---|---|
| Labeled for | Depression, Quitting smoking | Depression |
| Boxed warning | Yes | Yes |
| Pharmacy cost (NADAC) | $0.0785 per tablet 150 mg tablet | $17.20 per tablet 10 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once