What the FDA labels say about taking them together
Fentanyl and voriconazole
Voriconazole's FDA label of February 26, 2026 names fentanyl in its drug interactions section; the fentanyl labels PlainMeds reads (2) do not name voriconazole. The voriconazole label: “Fentanyl (CYP3A4 Inhibition) Increased Reduction in the dose of fentanyl and other long-acting opiates metabolized by CYP3A4 should be considered when concomitantly administered with VFEND.”
Check it at the source: the fentanyl FDA label on DailyMed (effective March 6, 2026, Hikma Pharmaceuticals USA Inc.); the voriconazole FDA label on DailyMed (effective February 26, 2026, Roerig).
What does the fentanyl label say about voriconazole?
Fentanyl's label (effective March 6, 2026) and its 1 other brand-application label do not name voriconazole in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Fentanyl Citrate), Hikma Pharmaceuticals USA Inc., effective March 6, 2026 (SPL set ce5db1c2-feb1-4ad2-847a-d02e865bd47e), via openFDA; the full label on DailyMed
What does the voriconazole label say about fentanyl?
Voriconazole label, drug interactionsFentanyl (CYP3A4 Inhibition) Increased Reduction in the dose of fentanyl and other long-acting opiates metabolized by CYP3A4 should be considered when concomitantly administered with VFEND.
Source: FDA drug label (Voriconazole, NDA208562), Xellia Pharmaceuticals USA LLC, effective January 11, 2023 (SPL set 9ec6eda2-2f15-423b-9ec6-819379a426e1), via openFDA
Source: FDA drug label (VFEND), NDA021630 (Pf Prism Cv), as published by Roerig, effective February 26, 2026 (SPL set ce3ef5cf-3087-4d92-9d94-9eb8287228db), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Fentanyl | Voriconazole | |
|---|---|---|
| Labeled for | Pain | Fungal infections |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | $1.79 per mL 100 mcg/2 mL vial | $1.88 per tablet 200 mg tablet |
| Shortage now | In shortage | A presentation being discontinued |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once