Voriconazole and Diclofenac Interaction
Drug interaction information between Voriconazole and Diclofenac.
Voriconazole and Diclofenac have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Voriconazole and Diclofenac. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Voriconazole interferes with the enzyme that clears diclofenac from your blood, which can cause the drug to reach higher levels than intended.
FDA Label Information
ibuprofen and diclofenac (CYP2C9 Inhibition) Increased Frequent monitoring for adverse reactions and toxicity related to NSAIDs.
Voriconazole Also Interacts With
- Norethindrone major
- Rifampin major
- Lurasidone major
- Pimozide major
- Ivabradine major
Diclofenac Also Interacts With
- Misoprostol moderate
- Warfarin moderate
- Celecoxib minor
- Digoxin minor
- Fluconazole minor
Frequently Asked Questions
What SPL severity band is on file for Voriconazole + Diclofenac?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Voriconazole has 50 labeled pairs on file vs Diclofenac's 11. In the minor band specifically: Voriconazole has 33 (also Omeprazole, Ibuprofen, Alprazolam, Oxycodone); Diclofenac has 9 (also Celecoxib, Digoxin, Fluconazole, Indomethacin).
What mechanism field is on file for Voriconazole and Diclofenac?
Voriconazole interferes with the enzyme that clears diclofenac from your blood, which can cause the drug to reach higher levels than intended.
Voriconazole carries more major-labeled pairs than Diclofenac
SPL source-record counts only. This page's band is minor · classes on file: Voriconazole (Azole Antifungal); Diclofenac (Nonsteroidal Anti-Inflammatory Drug (NSAID)).
Voriconazole has 8 major-labeled pairs vs Diclofenac's 0. This page itself is in the minor band, not the major band.
8 major · 9 moderate · 33 minor · 50 total
- Other minor peers for Voriconazole
- Omeprazole
- Ibuprofen
- Alprazolam
- Oxycodone
0 major · 2 moderate · 9 minor · 11 total
- Other minor peers for Diclofenac
- Celecoxib
- Digoxin
- Fluconazole
- Indomethacin
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.