What the FDA labels say about taking them together
Diclofenac and voriconazole
Diclofenac's FDA label (Zipsor) of March 1, 2026 names voriconazole in its drug interactions section, and voriconazole's label names diclofenac too. The diclofenac label: “Clinical Impact Diclofenac is metabolized by cytochrome P450 enzymes, predominantly by CYP2C9. Co-administration of diclofenac with CYP2C9 inhibitors (e.g. …”
Check it at the source: the diclofenac FDA label on DailyMed (effective February 11, 2025, Haleon US Holdings LLC); the voriconazole FDA label on DailyMed (effective February 26, 2026, Roerig).
What does the diclofenac label say about voriconazole?
Zipsor label (Assertio Specialty Pharmaceuticals LLC, March 1, 2026), drug interactionsClinical Impact Diclofenac is metabolized by cytochrome P450 enzymes, predominantly by CYP2C9. Co-administration of diclofenac with CYP2C9 inhibitors (e.g. voriconazole) may enhance the exposure and toxicity of diclofenac whereas co- administration with CYP2C9 inducers (e.g. rifampin) may lead to compromised efficacy of diclofenac. Intervention: A dosage adjustment may be warranted when diclofenac is administered with CYP2C9 inhibitors or inducers [ see Clinical Pharmacology () ]
Source: FDA drug label (Zipsor, NDA022202), Assertio Specialty Pharmaceuticals LLC, effective March 1, 2026 (SPL set ed2a8868-78eb-47b8-8f46-0f70e2891e07), via openFDA
Source: FDA drug label (Voltaren Arthritis Pain), Haleon US Holdings LLC, effective February 11, 2025 (SPL set 30a94282-0892-442a-aa10-6525cbd4fe88), via openFDA; the full label on DailyMed
What does the voriconazole label say about diclofenac?
Voriconazole label, drug interactionsNSAIDs Non-Steroidal Anti-Inflammatory Drug including. ibuprofen and diclofenac (CYP2C9 Inhibition) Increased Frequent monitoring for adverse reactions and toxicity related to NSAIDs.
Source: FDA drug label (VFEND), NDA021630 (Pf Prism Cv), as published by Roerig, effective February 26, 2026 (SPL set ce3ef5cf-3087-4d92-9d94-9eb8287228db), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Diclofenac | Voriconazole | |
|---|---|---|
| Labeled for | Pain, Osteoarthritis, Rheumatoid arthritis, Migraine | Fungal infections |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | $0.0619 per tablet 75 mg tablet | $1.88 per tablet 200 mg tablet |
| Shortage now | A presentation being discontinued | A presentation being discontinued |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once