What the FDA labels say about taking them together
Cyclosporine and voriconazole
Cyclosporine's FDA label of August 10, 2026 names voriconazole in its drug interactions section, and voriconazole's label names cyclosporine too. The voriconazole label: “Cyclosporine (CYP3A4 Inhibition) AUC τ Significantly Increased;”
Check it at the source: the cyclosporine FDA label on DailyMed (effective August 10, 2026, Novartis Pharmaceuticals Corporation); the voriconazole FDA label on DailyMed (effective February 26, 2026, Roerig).
What does the cyclosporine label say about voriconazole?
Cyclosporine label, drug interactionsvoriconazole; quinupristin/ dalfopristin; colchicine
Source: FDA drug label (Neoral), Novartis Pharmaceuticals Corporation, effective August 10, 2026 (SPL set 94461af3-11f1-4670-95d4-2965b9538ae3), via openFDA; the full label on DailyMed
What does the voriconazole label say about cyclosporine?
Voriconazole label, drug interactionsCyclosporine (CYP3A4 Inhibition) AUC τ Significantly Increased;
Voriconazole label (Xellia Pharmaceuticals USA LLC, January 11, 2023), drug interactionsDrug/Drug Class (Mechanism of Interaction by Voriconazole): Cyclosporine (CYP3A4 Inhibition); Drug Plasma Exposure (C max and AUC τ): AUC τ Significantly Increased; No Significant Effect on C max; Recommendations for Drug Dosage Adjustment/Comments: When initiating therapy with Voriconazole for injection in patients already receiving cyclosporine, reduce the cyclosporine dose to one-half of the starting dose and follow with frequent monitoring of cyclosporine blood levels. Increased cyclosporine levels have been associated with nephrotoxicity. When Voriconazole for injection is discontinued, cyclosporine concentrations must be frequently monitored and the dose increased as necessary.
Source: FDA drug label (Voriconazole, NDA208562), Xellia Pharmaceuticals USA LLC, effective January 11, 2023 (SPL set 9ec6eda2-2f15-423b-9ec6-819379a426e1), via openFDA
Source: FDA drug label (VFEND), NDA021630 (Pf Prism Cv), as published by Roerig, effective February 26, 2026 (SPL set ce3ef5cf-3087-4d92-9d94-9eb8287228db), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Cyclosporine | Voriconazole | |
|---|---|---|
| Labeled for | Organ transplant rejection, Rheumatoid arthritis | Fungal infections |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | $1.04 per unit 0.05% eye emulsion | $1.88 per tablet 200 mg tablet |
| Shortage now | No current entry | A presentation being discontinued |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once