Vilazodone and Voriconazole Interaction
Drug interaction information between Vilazodone and Voriconazole.
Vilazodone and Voriconazole have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Vilazodone and Voriconazole. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Voriconazole slows down how fast your body breaks down vilazodone. This can cause the amount of vilazodone in your blood to rise to higher levels.
FDA Label Information
Strong CYP3A4 Inhibitors (e.g., itraconazole, clarithromycin, voriconazole) The concomitant use of vilazodone hydrochloride tablets and strong CYP3A4 inhibitors increased the exposure of vilazodone compared to the use of vilazodone hydrochloride tablets alone [see Clinical Pharmacology (12.3)].
Vilazodone Also Interacts With
- Linezolid major
- Tranylcypromine major
- Warfarin moderate
- Carbamazepine minor
- Clarithromycin minor
Voriconazole Also Interacts With
- Norethindrone major
- Rifampin major
- Lurasidone major
- Pimozide major
- Ivabradine major
Frequently Asked Questions
What SPL severity band is on file for Vilazodone + Voriconazole?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Voriconazole has 50 labeled pairs on file vs Vilazodone's 10. In the minor band specifically: Vilazodone has 7 (also Carbamazepine, Clarithromycin, Rifampin, Itraconazole); Voriconazole has 33 (also Omeprazole, Ibuprofen, Alprazolam, Oxycodone).
What mechanism field is on file for Vilazodone and Voriconazole?
Voriconazole slows down how fast your body breaks down vilazodone. This can cause the amount of vilazodone in your blood to rise to higher levels.
Voriconazole carries more major-labeled pairs than Vilazodone
SPL source-record counts only. This page's band is minor · classes on file: Vilazodone (SSRI / 5-HT1A Partial Agonist); Voriconazole (Azole Antifungal).
Voriconazole has 8 major-labeled pairs vs Vilazodone's 2. This page itself is in the minor band, not the major band.
2 major · 1 moderate · 7 minor · 10 total
- Other minor peers for Vilazodone
- Carbamazepine
- Clarithromycin
- Rifampin
- Itraconazole
8 major · 9 moderate · 33 minor · 50 total
- Other minor peers for Voriconazole
- Omeprazole
- Ibuprofen
- Alprazolam
- Oxycodone
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.