What the FDA labels say about taking them together
Vilazodone and voriconazole
Vilazodone's FDA label of May 22, 2024 names voriconazole in its drug interactions section; the voriconazole labels PlainMeds reads (3) do not name vilazodone. The vilazodone label: “The VIIBRYD dose should not exceed 20 mg once daily with the concomitant use of a strong CYP3A4 inhibitor.”
Check it at the source: the vilazodone FDA label on DailyMed (effective May 22, 2024, Teva Pharmaceuticals, Inc.); the voriconazole FDA label on DailyMed (effective February 26, 2026, Roerig).
What does the vilazodone label say about voriconazole?
Vilazodone label, drug interactionsConcomitant Drug Name or Drug Class: Strong CYP3A4 Inhibitors (e.g., itraconazole, clarithromycin, voriconazole); Clinical Rationale: The concomitant use of vilazodone hydrochloride and strong CYP3A4 inhibitors increased the exposure of vilazodone compared to the use of vilazodone hydrochloride alone [see Clinical Pharmacology ()].; Clinical Recommendation: The vilazodone hydrochloride dose should not exceed 20 mg once daily with the concomitant use of a strong CYP3A4 inhibitor [see Dosage and Administration (), Clinical Pharmacology ()].
Source: FDA drug label (Viibryd, NDA022567), Allergan, Inc., effective October 1, 2023 (SPL set 4c55ccfb-c4cf-11df-851a-0800200c9a66), via openFDA
Source: FDA drug label (Vilazodone Hydrochloride), Teva Pharmaceuticals, Inc., effective May 22, 2024 (SPL set 3a4745a0-de23-4b40-923e-0d7dfe6b8634), via openFDA; the full label on DailyMed
What does the voriconazole label say about vilazodone?
Voriconazole's label (effective February 26, 2026) and its 2 other brand-application labels do not name vilazodone in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (VFEND), NDA021630 (Pf Prism Cv), as published by Roerig, effective February 26, 2026 (SPL set ce3ef5cf-3087-4d92-9d94-9eb8287228db), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Vilazodone | Voriconazole | |
|---|---|---|
| Labeled for | Depression | Fungal infections |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | $0.732 per tablet 10 mg tablet | $1.88 per tablet 200 mg tablet |
| Shortage now | No current entry | A presentation being discontinued |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once