What the FDA labels say about taking them together
Digoxin and vilazodone
Vilazodone's FDA label of May 22, 2024 names digoxin in its drug interactions section; the digoxin labels PlainMeds reads (3) do not name vilazodone. The vilazodone label: “Concomitant use of VIIBRYD increased digoxin concentrations.”
Check it at the source: the digoxin FDA label on DailyMed (effective December 5, 2024, Advanz Pharma (US) Corp.); the vilazodone FDA label on DailyMed (effective May 22, 2024, Teva Pharmaceuticals, Inc.).
What does the digoxin label say about vilazodone?
Digoxin's label (effective December 5, 2024) and its 2 other brand-application labels do not name vilazodone in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (LANOXIN), Advanz Pharma (US) Corp., effective December 5, 2024 (SPL set d91e3646-4c63-4512-ab22-db39c085c4dc), via openFDA; the full label on DailyMed
What does the vilazodone label say about digoxin?
Vilazodone label, drug interactionsConcomitant use of vilazodone hydrochloride increased digoxin concentrations [see Clinical Pharmacology ( 12.3 )].
Source: FDA drug label (Viibryd, NDA022567), Allergan, Inc., effective October 1, 2023 (SPL set 4c55ccfb-c4cf-11df-851a-0800200c9a66), via openFDA
Source: FDA drug label (Vilazodone Hydrochloride), Teva Pharmaceuticals, Inc., effective May 22, 2024 (SPL set 3a4745a0-de23-4b40-923e-0d7dfe6b8634), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Digoxin | Vilazodone | |
|---|---|---|
| Labeled for | Heart failure, Atrial fibrillation | Depression |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | $0.133 per tablet 125 mcg tablet | $0.732 per tablet 10 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once