What the FDA labels say about taking them together
Clonazepam and vigabatrin
Vigabatrin's FDA label of October 20, 2021 names clonazepam in its drug interactions section; clonazepam's label does not name vigabatrin itself but warns about its class (Anti-seizure medicines). The vigabatrin label: “Clonazepam SABRIL may moderately increase the C max of clonazepam resulting in an increase of clonazepam-associated adverse reactions.”
Check it at the source: the clonazepam FDA label on DailyMed (effective December 1, 2025, H2-Pharma, LLC); the vigabatrin FDA label on DailyMed (effective October 20, 2021, Lundbeck Pharmaceuticals LLC).
What does the clonazepam label say about vigabatrin?
Clonazepam's label does not name vigabatrin itself; it warns about its class (Anti-seizure medicines):
Clonazepam label, warningsSuicidal Behavior and Ideation Antiepileptic drugs (AEDs), including Klonopin, increase the risk of suicidal thoughts or behavior in patients taking these drugs for any indication.
Clonazepam label, warningsPatients treated with any AED for any indication should be monitored for the emergence or worsening of depression, suicidal thoughts or behavior, and/or any unusual changes in mood or behavior.
Source: FDA drug label (Klonopin), NDA017533 (Cheplapharm), as published by H2-Pharma, LLC, effective December 1, 2025 (SPL set cfa0d79a-843c-4b88-95a1-e9511d649ca1), via openFDA; the full label on DailyMed
What does the vigabatrin label say about clonazepam?
Vigabatrin label, drug interactionsClonazepam SABRIL may moderately increase the C max of clonazepam resulting in an increase of clonazepam-associated adverse reactions [see Clinical Pharmacology ( 12.3 )].
Source: FDA drug label (Vigafyde, NDA217684), Upsher-Smith Laboratories, LLC, effective November 1, 2025 (SPL set 8d3d6316-33ab-41e8-9485-4495c218be56), via openFDA
Source: FDA drug label (SABRIL), Lundbeck Pharmaceuticals LLC, effective October 20, 2021 (SPL set a88ac1b4-e2c9-45c0-b321-4785902172e3), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Clonazepam | Vigabatrin | |
|---|---|---|
| Labeled for | Seizures and epilepsy, Anxiety | n/a |
| Boxed warning | Yes | Yes |
| Pharmacy cost (NADAC) | $0.0244 per tablet 1 mg tablet | n/a |
| Shortage now | In shortage | A presentation being discontinued |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once