What the FDA labels say about taking them together
Digoxin and vibegron
Vibegron's FDA label of April 1, 2025 names digoxin in its drug interactions section; the digoxin labels PlainMeds reads (3) do not name vibegron. The vibegron label: “DRUG INTERACTIONS Concomitant use of GEMTESA increases digoxin maximal concentrations (C max ) and systemic exposure as assessed by area under the concentration-time curve (AUC).”
Check it at the source: the digoxin FDA label on DailyMed (effective December 5, 2024, Advanz Pharma (US) Corp.); the vibegron FDA label on DailyMed (effective April 1, 2025, Sumitomo Pharma America, Inc.).
What does the digoxin label say about vibegron?
Digoxin's label (effective December 5, 2024) and its 2 other brand-application labels do not name vibegron in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (LANOXIN), Advanz Pharma (US) Corp., effective December 5, 2024 (SPL set d91e3646-4c63-4512-ab22-db39c085c4dc), via openFDA; the full label on DailyMed
What does the vibegron label say about digoxin?
Vibegron label, drug interactionsDRUG INTERACTIONS Concomitant use of GEMTESA increases digoxin maximal concentrations (C max ) and systemic exposure as assessed by area under the concentration-time curve (AUC) [see Clinical Pharmacology ( 12.3 )].
Source: FDA drug label (GEMTESA), Sumitomo Pharma America, Inc., effective April 1, 2025 (SPL set 25f21d25-14f8-4fda-91f6-7aa8b68aa1c8), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Digoxin | Vibegron | |
|---|---|---|
| Labeled for | Heart failure, Atrial fibrillation | Overactive bladder |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $0.133 per tablet 125 mcg tablet | $16.46 per tablet 75 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once