What the FDA labels say about taking them together
Rifampin and verapamil
Verapamil's FDA label of April 6, 2026 names rifampin in its drug interactions section; the rifampin label PlainMeds reads does not name verapamil. The verapamil label: “Inducers of CYP3A4 (e.g., rifampin) have caused a lowering of plasma levels of verapamil.”
Check it at the source: the rifampin FDA label on DailyMed (effective February 11, 2026, Lupin Pharmaceuticals, Inc.); the verapamil FDA label on DailyMed (effective April 6, 2026, Zydus Pharmaceuticals (USA) Inc.).
What does the rifampin label say about verapamil?
Rifampin's label (effective February 11, 2026) does not name verapamil in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (rifampin), Lupin Pharmaceuticals, Inc., effective February 11, 2026 (SPL set b56004f0-f23d-47f6-80c7-39884fccbccc), via openFDA; the full label on DailyMed
What does the verapamil label say about rifampin?
Verapamil label, drug interactionsClinically significant interactions have been reported with inhibitors of CYP3A4 (e.g., erythromycin, ritonavir) causing elevation of plasma levels of verapamil while inducers of CYP3A4 (e.g., rifampin) have caused a lowering of plasma levels of verapamil.
Verapamil Hydrochloride label (Wilshire Pharmaceuticals, Inc., November 27, 2024), drug interactionsInducers of CYP3A4 (e.g., rifampin) have caused a lowering of plasma levels of verapamil.
Source: FDA drug label (Verapamil Hydrochloride, NDA020943), Wilshire Pharmaceuticals, Inc., effective November 27, 2024 (SPL set 5f665d08-e1e4-422a-88c2-d8834abf9e1a), via openFDA
Source: FDA drug label (Verapamil hydrochloride), Zydus Pharmaceuticals (USA) Inc., effective April 6, 2026 (SPL set e19ab8d8-dae5-489d-9805-7e7407bea06d), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Rifampin | Verapamil | |
|---|---|---|
| Labeled for | n/a | High blood pressure, Atrial fibrillation, Angina |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $0.679 per capsule 300 mg capsule | $0.191 per tablet 180 mg tablet |
| Shortage now | In shortage | A presentation being discontinued |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once