What the FDA labels say about taking them together
Indomethacin and vasopressin
Vasopressin's FDA label of February 21, 2025 names indomethacin in its drug interactions section; the indomethacin labels PlainMeds reads (4) do not name vasopressin. The vasopressin label: “DRUG INTERACTIONS Pressor effects of catecholamines and Vasostrict ® are expected to be additive. Indomethacin may prolong effects of Vasostrict ®. …”
Check it at the source: the indomethacin FDA label on DailyMed (effective December 19, 2025, Glenmark Pharmaceuticals Inc., USA); the vasopressin FDA label on DailyMed (effective February 21, 2025, Baxter Healthcare Corporation).
What does the indomethacin label say about vasopressin?
Indomethacin's label (effective December 19, 2025) and its 3 other brand-application labels do not name vasopressin in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Indomethacin), Glenmark Pharmaceuticals Inc., USA, effective December 19, 2025 (SPL set f7ed39e2-5431-4e47-935c-c7441d058f94), via openFDA; the full label on DailyMed
What does the vasopressin label say about indomethacin?
Vasopressin label, drug interactionsIndomethacin may prolong effects of Vasopressin in Sodium Chloride Injection.
Vasostrict label (Par Health USA, LLC, April 21, 2026), drug interactionsDRUG INTERACTIONS Pressor effects of catecholamines and Vasostrict ® are expected to be additive. ( 7.1 ) Indomethacin may prolong effects of Vasostrict ® . ( 7.2 ) Co-administration of ganglionic blockers or drugs causing SIADH may increase the pressor response. ( 7.3 , 7.4 ) Co-administration of drugs causing diabetes insipidus may decrease the pressor response.
Vasopressin In 0.9% Sodium Chloride label (Long Grove Pharmaceuticals, LLC, June 17, 2025), drug interactionsDRUG INTERACTIONS Pressor effects of catecholamines and Vasopressin in Sodium Chloride Injection are expected to be additive. ( 7.1 ) Indomethacin may prolong effects of Vasopressin in Sodium Chloride Injection. ( 7.2 ) Co-administration of ganglionic blockers or drugs causing SIADH may increase the pressor response. ( 7.3 , 7.4 ) Co-administration of drugs causing diabetes insipidus may decrease the pressor response.
Vasopressin label (American Regent, Inc., October 31, 2024), drug interactionsDRUG INTERACTIONS Pressor effects of catecholamines and vasopressin injection are expected to be additive. ( 7.1 ) Indomethacin may prolong effects of vasopressin injection. ( 7.2 ) Co-administration of ganglionic blockers or drugs causing SIADH (syndrome of inappropriate antidiuretic hormone secretion) may increase the pressor response. ( 7.3 , 7.4 ) Co-administration of drugs causing diabetes insipidus may decrease the pressor response.
Source: FDA drug label (Vasostrict, NDA204485), Par Health USA, LLC, effective April 21, 2026 (SPL set b1147beb-743e-4c62-8927-91192447f8b8), via openFDA
Source: FDA drug label (Vasopressin In 0.9% Sodium Chloride, NDA217766), Long Grove Pharmaceuticals, LLC, effective June 17, 2025 (SPL set bf4b0b63-0055-40d8-b331-7f9f1ea3214c), via openFDA
Source: FDA drug label (Vasopressin, NDA212593), American Regent, Inc., effective October 31, 2024 (SPL set 0ab267f4-9ec9-44fd-8521-f975074667d9), via openFDA
Source: FDA drug label (Vasopressin in 0.9% Sodium Chloride), Baxter Healthcare Corporation, effective February 21, 2025 (SPL set b5b2c367-6b7e-40be-a296-c4632f3e783f), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Indomethacin | Vasopressin | |
|---|---|---|
| Labeled for | Rheumatoid arthritis, Osteoarthritis | n/a |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | $0.210 per capsule 75 mg capsule | n/a |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once