What the FDA labels say about taking them together
Chlorpromazine and valproic acid
Valproic acid's FDA label of January 24, 2025 names chlorpromazine in its drug interactions section; the chlorpromazine label PlainMeds reads does not name valproic acid. The valproic acid label: “Chlorpromazine A study involving the administration of 100 to 300 mg/day of chlorpromazine to schizophrenic patients already receiving valproate (200 mg BID) revealed a 15% increase in trough plasma levels of valproate.”
Check it at the source: the chlorpromazine FDA label on DailyMed (effective May 12, 2026, Amneal Pharmaceuticals NY LLC); the valproic acid FDA label on DailyMed (effective January 24, 2025, PAI Holdings, LLC dba PAI Pharma).
What does the chlorpromazine label say about valproic acid?
Chlorpromazine's label (effective May 12, 2026) does not name valproic acid in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (CHLORPROMAZINE HYDROCHLORIDE), Amneal Pharmaceuticals NY LLC, effective May 12, 2026 (SPL set aa086a21-de85-4b03-af58-49b70acf8cf0), via openFDA; the full label on DailyMed
What does the valproic acid label say about chlorpromazine?
Valproic acid label, drug interactionsChlorpromazine A study involving the administration of 100 to 300 mg/day of chlorpromazine to schizophrenic patients already receiving valproate (200 mg BID) revealed a 15% increase in trough plasma levels of valproate.
Source: FDA drug label (VALPROIC ACID), PAI Holdings, LLC dba PAI Pharma, effective January 24, 2025 (SPL set 7d5cb52e-37dd-4dfa-a6f4-09f9548846c6), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Chlorpromazine | Valproic acid | |
|---|---|---|
| Labeled for | Schizophrenia, Nausea and vomiting | Seizures and epilepsy, Migraine |
| Boxed warning | Yes | Yes |
| Pharmacy cost (NADAC) | $0.552 per tablet 100 mg tablet | $0.243 per capsule 250 mg capsule |
| Shortage now | No current entry | Listed; available |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once