What the FDA labels say about taking them together
Umeclidinium/vilanterol and voriconazole
Umeclidinium/vilanterol's FDA label of June 2, 2023 names voriconazole in its warnings and precautions section; the voriconazole labels PlainMeds reads (3) do not name umeclidinium/vilanterol. The umeclidinium/vilanterol label: “Interactions with Strong Cytochrome P450 3A4 Inhibitors Caution should be exercised when considering the coadministration of ANORO ELLIPTA with ketoconazole and other known strong cytochrome P450 3A4 (CYP3A4) inhibitors …”
Check it at the source: the umeclidinium/vilanterol FDA label on DailyMed (effective June 2, 2023, GlaxoSmithKline LLC); the voriconazole FDA label on DailyMed (effective February 26, 2026, Roerig).
What does the umeclidinium/vilanterol label say about voriconazole?
Umeclidinium/vilanterol label, warnings and precautionsInteractions with Strong Cytochrome P450 3A4 Inhibitors Caution should be exercised when considering the coadministration of ANORO ELLIPTA with ketoconazole and other known strong cytochrome P450 3A4 (CYP3A4) inhibitors (including, but not limited to, ritonavir, clarithromycin, conivaptan, indinavir, itraconazole, lopinavir, nefazodone, nelfinavir, saquinavir, telithromycin, troleandomycin, voriconazole) because increased cardiovascular adverse effects may occur [see Drug Interactions ( 7.1 ), Clinical Pharmacology ( 12.3 )].
Source: FDA drug label (Anoro Ellipta), GlaxoSmithKline LLC, effective June 2, 2023 (SPL set 2dbd0671-c565-40c5-bf0f-e324db26799c), via openFDA; the full label on DailyMed
What does the voriconazole label say about umeclidinium/vilanterol?
Voriconazole's label (effective February 26, 2026) and its 2 other brand-application labels do not name umeclidinium/vilanterol in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (VFEND), NDA021630 (Pf Prism Cv), as published by Roerig, effective February 26, 2026 (SPL set ce3ef5cf-3087-4d92-9d94-9eb8287228db), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Umeclidinium/vilanterol | Voriconazole | |
|---|---|---|
| Labeled for | COPD | Fungal infections |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $4.95 per inhaler 62.5-25 mcg inhaler | $1.88 per tablet 200 mg tablet |
| Shortage now | No current entry | A presentation being discontinued |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once