What the FDA labels say about taking them together
Triamterene and valsartan
Valsartan's FDA label of August 5, 2026 names triamterene in its drug interactions section; the triamterene label PlainMeds reads does not name valsartan. The valsartan label: “Concomitant use of valsartan with other agents that block the renin-angiotensin system, potassium-sparing diuretics, potassium supplements, salt substitutes containing potassium or other drugs that may increase …”
Check it at the source: the triamterene FDA label on DailyMed (effective December 5, 2024, Advanz Pharma (US) Corp.); the valsartan FDA label on DailyMed (effective August 5, 2026, Macleods Pharmaceuticals Limited).
What does the triamterene label say about valsartan?
Triamterene's label (effective December 5, 2024) does not name valsartan in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Dyrenium), Advanz Pharma (US) Corp., effective December 5, 2024 (SPL set ebb177c0-d45d-4443-a85a-e76bd9931a42), via openFDA; the full label on DailyMed
What does the valsartan label say about triamterene?
Valsartan label, drug interactionsConcomitant use of valsartan with other agents that block the renin-angiotensin system, potassium-sparing diuretics (e.g., spironolactone, triamterene, amiloride), potassium supplements, salt substitutes containing potassium or other drugs that may increase potassium levels (e.g., heparin) may lead to increases in serum potassium and in heart failure patients to increases in serum creatinine.
Source: FDA drug label (Valsartan), Macleods Pharmaceuticals Limited, effective August 5, 2026 (SPL set 251ccff4-bf86-453b-9d1c-e3c1ecfd3a46), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Triamterene | Valsartan | |
|---|---|---|
| Labeled for | Heart failure, Edema (fluid retention) | High blood pressure, Heart failure |
| Boxed warning | Yes | Yes |
| Pharmacy cost (NADAC) | $5.98 per capsule 50 mg capsule | $0.0963 per tablet 40 mg tablet |
| Shortage now | No current entry | A presentation being discontinued |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once