What the FDA labels say about taking them together
Phenytoin and trazodone
Phenytoin's FDA label of October 15, 2024 names trazodone in its drug interactions section, and trazodone's label names phenytoin too. The trazodone label: “Digoxin or Phenytoin: Monitor for increased digoxin or phenytoin serum levels.”
Check it at the source: the phenytoin FDA label on DailyMed (effective October 15, 2024, Mylan Pharmaceuticals Inc.); the trazodone FDA label on DailyMed (effective January 22, 2026, Zydus Pharmaceuticals USA Inc.).
What does the phenytoin label say about trazodone?
Phenytoin label, drug interactionsInteracting Agent: Other; Examples: Acute alcohol intake, amiodarone, chloramphenicol, chlordiazepoxide, disulfiram, estrogen, fluvastatin, isoniazid, methylphenidate, phenothiazines, salicylates, ticlopidine, tolbutamide, trazodone, warfarin
Source: FDA drug label (Phenytek), Mylan Pharmaceuticals Inc., effective October 15, 2024 (SPL set 0f94c791-8b07-4b41-927e-c9f28bec5f60), via openFDA; the full label on DailyMed
What does the trazodone label say about phenytoin?
Trazodone label, drug interactionsDigoxin or Phenytoin: Monitor for increased digoxin or phenytoin serum levels ( 7 ).
Source: FDA drug label (Trazodone Hydrochloride), Zydus Pharmaceuticals USA Inc., effective January 22, 2026 (SPL set 704aebf9-2fff-4ef3-8323-9ff0d7f0ffd9), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Phenytoin | Trazodone | |
|---|---|---|
| Labeled for | Seizures and epilepsy | Depression |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | $0.145 per capsule 100 mg capsule | $0.0307 per tablet 50 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once