What the FDA labels say about taking them together
Digoxin and trazodone
Trazodone's FDA label of January 22, 2026 names digoxin in its drug interactions section; the digoxin labels PlainMeds reads (3) do not name trazodone. The trazodone label: “Digoxin or Phenytoin: Monitor for increased digoxin or phenytoin serum levels.”
Check it at the source: the digoxin FDA label on DailyMed (effective December 5, 2024, Advanz Pharma (US) Corp.); the trazodone FDA label on DailyMed (effective January 22, 2026, Zydus Pharmaceuticals USA Inc.).
What does the digoxin label say about trazodone?
Digoxin's label (effective December 5, 2024) and its 2 other brand-application labels do not name trazodone in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (LANOXIN), Advanz Pharma (US) Corp., effective December 5, 2024 (SPL set d91e3646-4c63-4512-ab22-db39c085c4dc), via openFDA; the full label on DailyMed
What does the trazodone label say about digoxin?
Trazodone label, drug interactionsDigoxin or Phenytoin: Monitor for increased digoxin or phenytoin serum levels ( 7 ).
Source: FDA drug label (Trazodone Hydrochloride), Zydus Pharmaceuticals USA Inc., effective January 22, 2026 (SPL set 704aebf9-2fff-4ef3-8323-9ff0d7f0ffd9), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Digoxin | Trazodone | |
|---|---|---|
| Labeled for | Heart failure, Atrial fibrillation | Depression |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | $0.133 per tablet 125 mcg tablet | $0.0307 per tablet 50 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once