What the FDA labels say about taking them together
Probenecid and torsemide
Torsemide's FDA label of May 8, 2024 names probenecid in its drug interactions section; the probenecid label PlainMeds reads does not name torsemide. The torsemide label: “Coadministration of organic anion drugs (e.g., probenecid) that undergo significant renal tubular secretion have the potential to reduce secretion of torsemide into the proximal tubule and thereby decreases the diuretic …”
Check it at the source: the probenecid FDA label on DailyMed (effective January 5, 2021, Lannett Company, Inc.); the torsemide FDA label on DailyMed (effective May 8, 2024, Aurobindo Pharma Limited).
What does the probenecid label say about torsemide?
Probenecid's label (effective January 5, 2021) does not name torsemide in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Probenecid), Lannett Company, Inc., effective January 5, 2021 (SPL set ab497fd8-00c3-4364-b003-b39d21fbdf38), via openFDA; the full label on DailyMed
What does the torsemide label say about probenecid?
Torsemide label, drug interactionsCoadministration of organic anion drugs (e.g., probenecid) that undergo significant renal tubular secretion have the potential to reduce secretion of torsemide into the proximal tubule and thereby decreases the diuretic activity of torsemide. Monitor diuretic effect and blood pressure during coadministration.
Source: FDA drug label (Torsemide), Aurobindo Pharma Limited, effective May 8, 2024 (SPL set 55e88727-864e-4313-860c-31a6ca45168f), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Probenecid | Torsemide | |
|---|---|---|
| Labeled for | Gout | High blood pressure, Heart failure |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $0.636 per tablet 500 mg tablet | $0.0636 per tablet 20 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once