What the FDA labels say about taking them together
Tirzepatide and warfarin
Tirzepatide's FDA label of July 29, 2026 names warfarin in its drug interactions section; the warfarin label PlainMeds reads does not name tirzepatide. The tirzepatide label: “Monitor patients on oral medications dependent on threshold concentrations for efficacy and those with a narrow therapeutic index (e.g., warfarin) when concomitantly administered with MOUNJARO.”
Check it at the source: the tirzepatide FDA label on DailyMed (effective July 29, 2026, A-S Medication Solutions); the warfarin FDA label on DailyMed (effective May 29, 2026, Amneal Pharmaceuticals LLC).
What does the tirzepatide label say about warfarin?
Tirzepatide label, drug interactionsMonitor patients on oral medications dependent on threshold concentrations for efficacy and those with a narrow therapeutic index (e.g., warfarin) when concomitantly administered with MOUNJARO.
Source: FDA drug label (Zepbound, NDA217806), Eli Lilly and Company, effective August 28, 2026 (SPL set 487cd7e7-434c-4925-99fa-aa80b1cc776b), via openFDA
Source: FDA drug label (MOUNJARO), NDA215866 (Eli Lilly And Co), as published by A-S Medication Solutions, effective July 29, 2026 (SPL set 78aad975-4971-49fa-b4b0-6aa39f76d2e7), via openFDA; the full label on DailyMed
What does the warfarin label say about tirzepatide?
Warfarin's label (effective May 29, 2026) does not name tirzepatide in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Warfarin Sodium), Amneal Pharmaceuticals LLC, effective May 29, 2026 (SPL set 558b7a0d-5490-4c1b-802e-3ab3f1efe760), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Tirzepatide | Warfarin | |
|---|---|---|
| Labeled for | Type 2 diabetes, Heart attack and coronary artery disease, Weight management | Blood clots (DVT and PE), Atrial fibrillation |
| Boxed warning | Yes | Yes |
| Pharmacy cost (NADAC) | $538.68 per mL 10 mg/0.5 mL pen | $0.093 per tablet 2 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once