What the FDA labels say about taking them together
Phenytoin and ticagrelor
Phenytoin's FDA label of October 15, 2024 names ticagrelor in its drug interactions section, and ticagrelor's label names phenytoin too. The ticagrelor label: “Avoid use with strong inducers of CYP3A.”
Check it at the source: the phenytoin FDA label on DailyMed (effective October 15, 2024, Mylan Pharmaceuticals Inc.); the ticagrelor FDA label on DailyMed (effective May 7, 2026, AstraZeneca Pharmaceuticals LP).
What does the phenytoin label say about ticagrelor?
Phenytoin label, drug interactionsInteracting Agent: Antiplatelets; Examples: Ticagrelor
Source: FDA drug label (Phenytek), Mylan Pharmaceuticals Inc., effective October 15, 2024 (SPL set 0f94c791-8b07-4b41-927e-c9f28bec5f60), via openFDA; the full label on DailyMed
What does the ticagrelor label say about phenytoin?
Ticagrelor label, drug interactionsAvoid use with strong inducers of CYP3A (e.g., rifampin, phenytoin, carbamazepine and phenobarbital) [see Clinical Pharmacology (12.3) ].
Source: FDA drug label (BRILINTA), AstraZeneca Pharmaceuticals LP, effective May 7, 2026 (SPL set f7b3f443-e83d-4bf2-0e96-023448fed9a8), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Phenytoin | Ticagrelor | |
|---|---|---|
| Labeled for | Seizures and epilepsy | Heart attack and coronary artery disease, Stroke prevention |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | $0.145 per capsule 100 mg capsule | $0.253 per tablet 90 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once