What the FDA labels say about taking them together
Tetracycline and tigecycline
Tigecycline's FDA label of November 18, 2025 names tetracycline in its warnings and precautions section; the tetracycline label PlainMeds reads does not name tigecycline. The tigecycline label: “A decrease in fibula growth rate has been observed in premature infants given oral tetracycline in doses of 25 mg/kg every 6 hours.”
Check it at the source: the tetracycline FDA label on DailyMed (effective March 18, 2025, Heritage Pharmaceuticals Inc. d/b/a Avet Pharmaceuticals Inc.); the tigecycline FDA label on DailyMed (effective November 18, 2025, Wyeth Pharmaceuticals LLC, a subsidiary of Pfizer Inc.).
What does the tetracycline label say about tigecycline?
Tetracycline's label (effective March 18, 2025) does not name tigecycline in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (tetracycline hydrochloride), Heritage Pharmaceuticals Inc. d/b/a Avet Pharmaceuticals Inc., effective March 18, 2025 (SPL set eaa5b1bd-0927-46e4-b941-32fcc492d258), via openFDA; the full label on DailyMed
What does the tigecycline label say about tetracycline?
Tigecycline label, warnings and precautionsA decrease in fibula growth rate has been observed in premature infants given oral tetracycline in doses of 25 mg/kg every 6 hours.
Source: FDA drug label (Tygacil), NDA021821 (Pf Prism Cv), as published by Wyeth Pharmaceuticals LLC, a subsidiary of Pfizer Inc., effective November 18, 2025 (SPL set fd826e47-1b77-4ffd-bb22-fda3379903b0), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Tetracycline | Tigecycline | |
|---|---|---|
| Labeled for | Bacterial infections | Bacterial infections |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | $0.247 per capsule 250 mg capsule | n/a |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once