What the FDA labels say about taking them together
Tenofovir alafenamide and tenofovir disoproxil
Tenofovir alafenamide's FDA label of July 14, 2025 names tenofovir disoproxil in its warnings and precautions section; the tenofovir disoproxil labels PlainMeds reads (2) do not name tenofovir alafenamide.
Check it at the source: the tenofovir alafenamide FDA label on DailyMed (effective July 14, 2025, Gilead Sciences, Inc.); the tenofovir disoproxil FDA label on DailyMed (effective June 7, 2024, Aurobindo Pharma Limited).
What does the tenofovir alafenamide label say about tenofovir disoproxil?
Tenofovir alafenamide label, warnings and precautionsHepatomegaly with Steatosis Lactic acidosis and severe hepatomegaly with steatosis, including fatal cases, have been reported with the use of nucleoside analogs, including tenofovir disoproxil fumarate (TDF), another prodrug of tenofovir, alone or in combination with other antiretrovirals.
Source: FDA drug label (VEMLIDY), Gilead Sciences, Inc., effective July 14, 2025 (SPL set 72e6b33c-0351-4070-9172-eeaa186c01d2), via openFDA; the full label on DailyMed
What does the tenofovir disoproxil label say about tenofovir alafenamide?
Tenofovir disoproxil's label (effective June 7, 2024) and its 1 other brand-application label do not name tenofovir alafenamide in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Tenofovir Disoproxil Fumarate), Aurobindo Pharma Limited, effective June 7, 2024 (SPL set a75c6be8-3719-4bb3-8a9e-06e5254d2a82), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Tenofovir alafenamide | Tenofovir disoproxil | |
|---|---|---|
| Labeled for | Hepatitis B | HIV, Hepatitis B |
| Boxed warning | Yes | Yes |
| Pharmacy cost (NADAC) | $51.98 per tablet 25 mg tablet | $0.294 per tablet 300 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once