Telmisartan and Digoxin Interaction
Drug interaction information between Telmisartan and Digoxin.
Telmisartan and Digoxin have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Telmisartan and Digoxin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Telmisartan can raise the amount of digoxin in your blood by changing how your body processes and removes it.
FDA Label Information
Digoxin: When telmisartan was co-administered with digoxin, median increases in digoxin peak plasma concentration (49%) and in trough concentration (20%) were observed. Therefore, monitor digoxin levels when initiating, adjusting, and discontinuing telmisartan for the purpose of keeping the digoxin level within the therapeutic range.
Telmisartan Also Interacts With
View all Telmisartan interactions →Digoxin Also Interacts With
- Nicardipine major
- Posaconazole major
- Sotalol moderate
- Dofetilide moderate
- Ivabradine moderate
Frequently Asked Questions
What SPL severity band is on file for Telmisartan + Digoxin?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Digoxin has 120 labeled pairs on file vs Telmisartan's 4. In the minor band specifically: Telmisartan has 2 (also Lithium); Digoxin has 105 (also Metformin, Omeprazole, Ibuprofen, Diclofenac).
What mechanism field is on file for Telmisartan and Digoxin?
Telmisartan can raise the amount of digoxin in your blood by changing how your body processes and removes it.
Digoxin carries more major-labeled pairs than Telmisartan
SPL source-record counts only. This page's band is minor · classes on file: Telmisartan (Angiotensin II Receptor Blocker (ARB)); Digoxin (Cardiac Glycoside).
Digoxin has 2 major-labeled pairs vs Telmisartan's 1. This page itself is in the minor band, not the major band.
2 major · 13 moderate · 105 minor · 120 total
- Other minor peers for Digoxin
- Metformin
- Omeprazole
- Ibuprofen
- Diclofenac
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.