What the FDA labels say about taking them together
Digoxin and telmisartan
Digoxin's FDA label of December 5, 2024 names telmisartan in its drug interactions section, and telmisartan's label names digoxin too. The telmisartan label: “When telmisartan was co-administered with digoxin, median increases in digoxin peak plasma concentration (49%) and in trough concentration (20%) were observed.”
Check it at the source: the digoxin FDA label on DailyMed (effective December 5, 2024, Advanz Pharma (US) Corp.); the telmisartan FDA label on DailyMed (effective May 29, 2026, Alembic Pharmaceuticals Limited).
What does the digoxin label say about telmisartan?
Digoxin label, drug interactionsTelmisartan; 20-49%; NA; Measure serum digoxin concentrations before initiating concomitant drugs. Reduce digoxin concentrations by decreasing the dose by approximately 15-30% or by modifying the dosing frequency and continue monitoring.
Source: FDA drug label (Digoxin, NDA021648), Hikma Pharmaceuticals USA Inc., effective April 10, 2025 (SPL set 1b7e5c6e-e052-41b0-a4ce-05dfe62faaaf), via openFDA
Source: FDA drug label (LANOXIN), Advanz Pharma (US) Corp., effective December 5, 2024 (SPL set d91e3646-4c63-4512-ab22-db39c085c4dc), via openFDA; the full label on DailyMed
What does the telmisartan label say about digoxin?
Telmisartan label, drug interactionsWhen telmisartan was co-administered with digoxin, median increases in digoxin peak plasma concentration (49%) and in trough concentration (20%) were observed.
Source: FDA drug label (Telmisartan), Alembic Pharmaceuticals Limited, effective May 29, 2026 (SPL set 4be6575f-ea8d-4cd8-a49d-3d1c93f2621a), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Digoxin | Telmisartan | |
|---|---|---|
| Labeled for | Heart failure, Atrial fibrillation | High blood pressure, Heart attack and coronary artery disease |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | $0.133 per tablet 125 mcg tablet | $0.106 per tablet 20 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once