What the FDA labels say about taking them together
Probenecid and sulindac
Probenecid's FDA label of January 5, 2021 names sulindac in its drug interactions section, and sulindac's label names probenecid too. The probenecid label: “Probenecid given concomitantly with sulindac had only a slight effect on plasma sulfide levels, while plasma levels of sulindac and sulfone were increased.”
Check it at the source: the probenecid FDA label on DailyMed (effective January 5, 2021, Lannett Company, Inc.); the sulindac FDA label on DailyMed (effective December 20, 2024, Epic Pharma, LLC).
What does the probenecid label say about sulindac?
Probenecid label, drug interactionsProbenecid given concomitantly with sulindac had only a slight effect on plasma sulfide levels, while plasma levels of sulindac and sulfone were increased.
Source: FDA drug label (Probenecid), Lannett Company, Inc., effective January 5, 2021 (SPL set ab497fd8-00c3-4364-b003-b39d21fbdf38), via openFDA; the full label on DailyMed
What does the sulindac label say about probenecid?
Sulindac label, drug interactionsProbenecid Probenecid given concomitantly with sulindac had only a slight effect on plasma sulfide levels, while plasma levels of sulindac and sulfone were increased.
Source: FDA drug label (SULINDAC), Epic Pharma, LLC, effective December 20, 2024 (SPL set 96c73bd2-4577-487d-a642-bd8f91e94c3a), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Probenecid | Sulindac | |
|---|---|---|
| Labeled for | Gout | Osteoarthritis, Rheumatoid arthritis |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | $0.636 per tablet 500 mg tablet | $0.189 per tablet 150 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once