What the FDA labels say about taking them together
Furosemide and sulindac
Sulindac's FDA label of December 20, 2024 names furosemide in its drug interactions section; furosemide's label does not name sulindac itself but warns about its class (NSAIDs (nonsteroidal anti-inflammatory drugs)). The sulindac label: “Diuretics Clinical studies, as well as post marketing observations, have shown that sulindac can reduce the natriuretic effect of furosemide and thiazides in some patients.”
Check it at the source: the furosemide FDA label on DailyMed (effective September 30, 2025, Validus Pharmaceuticals LLC); the sulindac FDA label on DailyMed (effective December 20, 2024, Epic Pharma, LLC).
What does the furosemide label say about sulindac?
Furosemide's label does not name sulindac itself; it warns about its class (NSAIDs (nonsteroidal anti-inflammatory drugs)):
Furosemide label, drug interactionsThere are case reports of patients who developed increased BUN, serum creatinine and serum potassium levels, and weight gain when furosemide was used in conjunction with NSAIDs.
Source: FDA drug label (Lasix), Validus Pharmaceuticals LLC, effective September 30, 2025 (SPL set 2c9b4d8f-0770-482d-a9e6-9c616a440b1a), via openFDA; the full label on DailyMed
What does the sulindac label say about furosemide?
Sulindac label, drug interactionsDiuretics Clinical studies, as well as post marketing observations, have shown that sulindac can reduce the natriuretic effect of furosemide and thiazides in some patients.
Source: FDA drug label (SULINDAC), Epic Pharma, LLC, effective December 20, 2024 (SPL set 96c73bd2-4577-487d-a642-bd8f91e94c3a), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Furosemide | Sulindac | |
|---|---|---|
| Labeled for | Heart failure, High blood pressure, Edema (fluid retention) | Osteoarthritis, Rheumatoid arthritis |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | $0.490 per mL 20 mg/2 mL vial | $0.189 per tablet 150 mg tablet |
| Shortage now | In shortage | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once