What the FDA labels say about taking them together
Sorafenib and warfarin
Sorafenib's FDA label of August 28, 2023 names warfarin in its drug interactions section; the warfarin label PlainMeds reads does not name sorafenib. The sorafenib label: “Use of Warfarin The concomitant use of NEXAVAR and warfarin may increase the risk of bleeding or increased the INR.”
Check it at the source: the sorafenib FDA label on DailyMed (effective August 28, 2023, Bayer HealthCare Pharmaceuticals Inc.); the warfarin FDA label on DailyMed (effective May 29, 2026, Amneal Pharmaceuticals LLC).
What does the sorafenib label say about warfarin?
Sorafenib label, drug interactionsUse of Warfarin The concomitant use of NEXAVAR and warfarin may increase the risk of bleeding or increased the INR.
Sorafenib label, warnings and precautionsRisk of Bleeding with Concomitant Use of Warfarin Infrequent bleeding or elevations in the International Normalized Ratio (INR) have been reported in some patients taking warfarin while on NEXAVAR.
Source: FDA drug label (Nexavar), Bayer HealthCare Pharmaceuticals Inc., effective August 28, 2023 (SPL set b50667e4-5ebc-4968-a646-d605058dbef0), via openFDA; the full label on DailyMed
What does the warfarin label say about sorafenib?
Warfarin's label (effective May 29, 2026) does not name sorafenib in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Warfarin Sodium), Amneal Pharmaceuticals LLC, effective May 29, 2026 (SPL set 558b7a0d-5490-4c1b-802e-3ab3f1efe760), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Sorafenib | Warfarin | |
|---|---|---|
| Labeled for | n/a | Blood clots (DVT and PE), Atrial fibrillation |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | n/a | $0.093 per tablet 2 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once