What the FDA labels say about taking them together
Omeprazole and sofosbuvir/velpatasvir
Sofosbuvir/velpatasvir's FDA label of June 5, 2024 names omeprazole in its drug interactions section; the omeprazole labels PlainMeds reads (2) do not name sofosbuvir/velpatasvir. The sofosbuvir/velpatasvir label: “Proton-pump inhibitors (e.g., omeprazole) Coadministration of omeprazole or other proton-pump inhibitors is not recommended.”
Check it at the source: the omeprazole FDA label on DailyMed (effective April 22, 2024, Apotex Corp); the sofosbuvir/velpatasvir FDA label on DailyMed (effective June 5, 2024, Gilead Sciences, Inc.).
What does the omeprazole label say about sofosbuvir/velpatasvir?
Omeprazole's label (effective April 22, 2024) and its 1 other brand-application label do not name sofosbuvir/velpatasvir in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Omeprazole), Apotex Corp, effective April 22, 2024 (SPL set b83329ac-a65e-b3af-a3fb-c5a6c740e5e7), via openFDA; the full label on DailyMed
What does the sofosbuvir/velpatasvir label say about omeprazole?
Sofosbuvir/velpatasvir label, drug interactionsProton-pump inhibitors (e.g., omeprazole) Coadministration of omeprazole or other proton-pump inhibitors is not recommended.
Source: FDA drug label (Epclusa), Gilead Sciences, Inc., effective June 5, 2024 (SPL set 7f30631a-ee3b-4cfe-866b-964df3f0a44f), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Omeprazole | Sofosbuvir/velpatasvir | |
|---|---|---|
| Labeled for | Acid reflux and ulcers | Hepatitis C |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | $0.0295 per capsule 20 mg capsule | $278.03 per unit 400-100 |
| Shortage now | A presentation being discontinued | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once