What the FDA labels say about taking them together
Sodium zirconium cyclosilicate and tacrolimus
Sodium zirconium cyclosilicate's FDA label of February 8, 2024 names tacrolimus in its drug interactions section; the tacrolimus labels PlainMeds reads (4) do not name sodium zirconium cyclosilicate. The sodium zirconium cyclosilicate label: “In another drug-drug interaction study in healthy volunteers, co-administration of LOKELMA 15 g decreased the systemic exposures of tacrolimus, likely due to LOKELMA’s action on elevating gastric pH.”
Check it at the source: the sodium zirconium cyclosilicate FDA label on DailyMed (effective February 8, 2024, AstraZeneca Pharmaceuticals LP); the tacrolimus FDA label on DailyMed (effective July 17, 2026, Stellon Biotech Inc.).
What does the sodium zirconium cyclosilicate label say about tacrolimus?
Sodium zirconium cyclosilicate label, drug interactionsIn another drug-drug interaction study in healthy volunteers, co-administration of LOKELMA 15 g decreased the systemic exposures of tacrolimus (Figure 2), likely due to LOKELMA’s action on elevating gastric pH.
Source: FDA drug label (LOKELMA), AstraZeneca Pharmaceuticals LP, effective February 8, 2024 (SPL set 90bf8e28-748d-4e4b-a19f-9cf483370eff), via openFDA; the full label on DailyMed
What does the tacrolimus label say about sodium zirconium cyclosilicate?
Tacrolimus's label (effective July 17, 2026) and its 3 other brand-application labels do not name sodium zirconium cyclosilicate in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Tacrolimus), Stellon Biotech Inc., effective July 17, 2026 (SPL set 6b89e8a4-9f11-42e3-8e79-fe617e7c461f), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Sodium zirconium cyclosilicate | Tacrolimus | |
|---|---|---|
| Labeled for | n/a | Organ transplant rejection, Eczema (atopic dermatitis) |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | $28.33 per packet 10 gram powder packet | $0.970 per gram 0.1% ointment |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once