What the FDA labels say about taking them together
Digoxin and simvastatin
Simvastatin's FDA label of March 28, 2025 names digoxin in its drug interactions section; the digoxin labels PlainMeds reads (3) do not name simvastatin. The simvastatin label: “Obtain INR before ZOCOR initiation and monitor INR during ZOCOR dosage initiation or adjustment. Digoxin: During ZOCOR initiation, monitor digoxin levels.”
Check it at the source: the digoxin FDA label on DailyMed (effective December 5, 2024, Advanz Pharma (US) Corp.); the simvastatin FDA label on DailyMed (effective March 28, 2025, Organon LLC).
What does the digoxin label say about simvastatin?
Digoxin's label (effective December 5, 2024) and its 2 other brand-application labels do not name simvastatin in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (LANOXIN), Advanz Pharma (US) Corp., effective December 5, 2024 (SPL set d91e3646-4c63-4512-ab22-db39c085c4dc), via openFDA; the full label on DailyMed
What does the simvastatin label say about digoxin?
Simvastatin label, drug interactionsObtain INR before ZOCOR initiation and monitor INR during ZOCOR dosage initiation or adjustment. ( 7.2 ) Digoxin: During ZOCOR initiation, monitor digoxin levels.
Source: FDA drug label (ZOCOR), Organon LLC, effective March 28, 2025 (SPL set 8f55d5de-5a4f-4a39-8c84-c53976dd6af9), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Digoxin | Simvastatin | |
|---|---|---|
| Labeled for | Heart failure, Atrial fibrillation | Heart attack and coronary artery disease, High cholesterol, High triglycerides |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $0.133 per tablet 125 mcg tablet | $0.0321 per tablet 20 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once