What the FDA labels say about taking them together
Sertraline and tranylcypromine
Sertraline's FDA label of August 8, 2023 names tranylcypromine in its drug interactions section; tranylcypromine's label does not name sertraline itself but warns about its class (serotonin reuptake inhibitors). The sertraline label: “The concomitant use of SSRIs including ZOLOFT and MAOIs increases the risk of serotonin syndrome.”
Check it at the source: the sertraline FDA label on DailyMed (effective August 8, 2023, Viatris Specialty LLC); the tranylcypromine FDA label on DailyMed (effective July 2, 2025, Advanz Pharma (US) Corp.).
What does the sertraline label say about tranylcypromine?
Sertraline label, drug interactionsMonoamine Oxidase Inhibitors (MAOIs) Clinical Impact: The concomitant use of SSRIs including ZOLOFT and MAOIs increases the risk of serotonin syndrome. Intervention: ZOLOFT is contraindicated in patients taking MAOIs, including MAOIs such as linezolid or intravenous methylene blue [See,, ]. Examples: selegiline, tranylcypromine, isocarboxazid, phenelzine, linezolid, methylene blue
Source: FDA drug label (Sertraline Hydrochloride, NDA020990), Mylan Pharmaceuticals Inc., effective September 15, 2024 (SPL set 1a58062b-e635-431a-908d-2651c6a4a21c), via openFDA
Source: FDA drug label (Zoloft), Viatris Specialty LLC, effective August 8, 2023 (SPL set fda754f6-d0f3-4dce-a17a-927d64f912f7), via openFDA; the full label on DailyMed
What does the tranylcypromine label say about sertraline?
Tranylcypromine's label does not name sertraline itself; it warns about its class (serotonin reuptake inhibitors):
Tranylcypromine label, drug interactionsOther MAOIs (e.g., linezolid, intravenous methylene blue, selective MAOIs) Selective serotonin reuptake inhibitors (SSRIs) and serotonin and norepinephrine reuptake inhibitors (SNRIs) Tricyclic antidepressants Amoxapine, bupropion, maprotiline, nefazodone, trazodone, vilazodone, vortioxetine Contraindicated a SS for all antidepressants For MAOIs, increased MAO inhibition and risk of adverse reactions, SS, and HR g Amphetamines and methylphenidates and derivatives Contraindicated a HR Sympathomimetic drugs** …
Tranylcypromine label, contraindicationsCONTRAINDICATIONS Concomitant use or use in rapid succession with other MAOIs; selective serotonin reuptake inhibitors; serotonin and norepinephrine reuptake inhibitors; tricyclic antidepressants; sympathomimetic drugs; and numerous other drugs.
Source: FDA drug label (PARNATE), Advanz Pharma (US) Corp., effective July 2, 2025 (SPL set b72d8187-dfcc-4ea0-b5e9-c0be95b69a27), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Sertraline | Tranylcypromine | |
|---|---|---|
| Labeled for | Depression, Anxiety | Depression |
| Boxed warning | Yes | Yes |
| Pharmacy cost (NADAC) | $0.0507 per tablet 100 mg tablet | $0.591 per tablet 10 mg tablet |
| Shortage now | No current entry | A presentation being discontinued |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once