What the FDA labels say about taking them together
Sertraline and stiripentol
Stiripentol's FDA label of April 27, 2026 names sertraline in its drug interactions section; the sertraline labels PlainMeds reads (3) do not name stiripentol. The stiripentol label: “Because of potential drug-drug interactions, consider dose adjustment of CYP1A2 substrates, CYP2B6 substrates, and CYP3A4 substrates, as clinically appropriate, when administered concomitantly with DIACOMIT.”
Check it at the source: the sertraline FDA label on DailyMed (effective August 8, 2023, Viatris Specialty LLC); the stiripentol FDA label on DailyMed (effective April 27, 2026, BIOCODEX, INC.).
What does the sertraline label say about stiripentol?
Sertraline's label (effective August 8, 2023) and its 2 other brand-application labels do not name stiripentol in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Zoloft), Viatris Specialty LLC, effective August 8, 2023 (SPL set fda754f6-d0f3-4dce-a17a-927d64f912f7), via openFDA; the full label on DailyMed
What does the stiripentol label say about sertraline?
Stiripentol label, drug interactionsBecause of potential drug-drug interactions, consider dose adjustment of CYP1A2 substrates (e.g., theophylline, caffeine), CYP2B6 substrates (e.g., sertraline, thiotepa), and CYP3A4 substrates (e.g., midazolam, triazolam, quinidine), as clinically appropriate, when administered concomitantly with DIACOMIT.
Source: FDA drug label (Diacomit), BIOCODEX, INC., effective April 27, 2026 (SPL set 58304ba8-9779-4658-811e-94ffe08c3f16), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Sertraline | Stiripentol | |
|---|---|---|
| Labeled for | Depression, Anxiety | n/a |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | $0.0507 per tablet 100 mg tablet | n/a |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once