What the FDA labels say about taking them together
Sertraline and sotalol
Sertraline's FDA label of August 8, 2023 names sotalol in its drug interactions section; the sotalol labels PlainMeds reads (3) do not name sertraline.
Check it at the source: the sertraline FDA label on DailyMed (effective August 8, 2023, Viatris Specialty LLC); the sotalol FDA label on DailyMed (effective December 16, 2024, Legacy Pharma USA, Inc.).
What does the sertraline label say about sotalol?
Sertraline label, drug interactionsClass III antiarrhythmics (e.g., amiodarone, sotalol); and others (e.g., pentamidine, levomethadyl acetate, methadone, halofantrine, mefloquine, dolasetron mesylate, probucol or tacrolimus).
Source: FDA drug label (Zoloft), Viatris Specialty LLC, effective August 8, 2023 (SPL set fda754f6-d0f3-4dce-a17a-927d64f912f7), via openFDA; the full label on DailyMed
What does the sotalol label say about sertraline?
Sotalol's label (effective December 16, 2024) and its 2 other brand-application labels do not name sertraline in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (BETAPACE), Legacy Pharma USA, Inc., effective December 16, 2024 (SPL set a6a7702f-36c9-45db-b640-453dc324baee), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Sertraline | Sotalol | |
|---|---|---|
| Labeled for | Depression, Anxiety | Atrial fibrillation |
| Boxed warning | Yes | Yes |
| Pharmacy cost (NADAC) | $0.0507 per tablet 100 mg tablet | $0.0707 per tablet 80 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once