What the FDA labels say about taking them together
Pimozide and sertraline
Pimozide's FDA label of August 12, 2026 names sertraline in its contraindications section, and sertraline's label names pimozide too. The sertraline label: “Increased plasma concentrations of pimozide, a drug with a narrow therapeutic index, may increase the risk of QTc prolongation and ventricular arrhythmias.”
Check it at the source: the pimozide FDA label on DailyMed (effective August 12, 2026, Par Health USA, LLC); the sertraline FDA label on DailyMed (effective August 8, 2023, Viatris Specialty LLC).
What does the pimozide label say about sertraline?
Pimozide label, contraindicationsConcomitant use of pimozide in patients taking sertraline is contraindicated (See PRECAUTIONS – DRUG INTERACTIONS ).
Pimozide label, drug interactionsConcomitant administration of pimozide and sertraline should be contraindicated (See CONTRAINDICATIONS ).
Source: FDA drug label (Pimozide), Par Health USA, LLC, effective August 12, 2026 (SPL set 70b079e2-a1f7-4a93-8685-d60a4d7c1280), via openFDA; the full label on DailyMed
What does the sertraline label say about pimozide?
Sertraline label, contraindicationsTaking pimozide [See Drug Interactions (7.1) ].
Sertraline label, drug interactionsPimozide Clinical Impact: Increased plasma concentrations of pimozide, a drug with a narrow therapeutic index, may increase the risk of QTc prolongation and ventricular arrhythmias. Intervention: Concomitant use of pimozide and ZOLOFT is contraindicated [See ].
Sertraline Hcl label (Almatica Pharma LLC, August 24, 2023), contraindicationsConcomitant use of monoamine oxidase inhibitors (MAOIs), or use within 14 days of stopping MAOIs ( 4 , 7.1 ) Concomitant use of pimozide ( 4 , 7.1 ) Known hypersensitivity to sertraline or excipients
Source: FDA drug label (Sertraline Hcl, NDA215133), Almatica Pharma LLC, effective August 24, 2023 (SPL set 8c8bcba9-eaeb-aa44-f9ea-b580de55a439), via openFDA
Source: FDA drug label (Zoloft), Viatris Specialty LLC, effective August 8, 2023 (SPL set fda754f6-d0f3-4dce-a17a-927d64f912f7), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Pimozide | Sertraline | |
|---|---|---|
| Labeled for | n/a | Depression, Anxiety |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | $1.23 per tablet 1 mg tablet | $0.0507 per tablet 100 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once