What the FDA labels say about taking them together
Sarilumab and warfarin
Sarilumab's FDA label of February 27, 2026 names warfarin in its drug interactions section; the warfarin label PlainMeds reads does not name sarilumab. The sarilumab label: “Upon initiation or discontinuation of KEVZARA, in patients being treated with CYP substrate medicinal products, perform therapeutic monitoring of effect (e.g., warfarin) or drug concentration (e.g., theophylline) and …”
Check it at the source: the sarilumab FDA label on DailyMed (effective February 27, 2026, Sanofi-Aventis U.S. LLC); the warfarin FDA label on DailyMed (effective May 29, 2026, Amneal Pharmaceuticals LLC).
What does the sarilumab label say about warfarin?
Sarilumab label, drug interactionsUpon initiation or discontinuation of KEVZARA, in patients being treated with CYP substrate medicinal products, perform therapeutic monitoring of effect (e.g., warfarin) or drug concentration (e.g., theophylline) and adjust the individual dose of the medicinal product as needed.
Source: FDA drug label (KEVZARA), Sanofi-Aventis U.S. LLC, effective February 27, 2026 (SPL set 827bc01c-d379-4266-a18c-c7f904b76af3), via openFDA; the full label on DailyMed
What does the warfarin label say about sarilumab?
Warfarin's label (effective May 29, 2026) does not name sarilumab in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Warfarin Sodium), Amneal Pharmaceuticals LLC, effective May 29, 2026 (SPL set 558b7a0d-5490-4c1b-802e-3ab3f1efe760), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Sarilumab | Warfarin | |
|---|---|---|
| Labeled for | Rheumatoid arthritis | Blood clots (DVT and PE), Atrial fibrillation |
| Boxed warning | Yes | Yes |
| Pharmacy cost (NADAC) | $2,075.30 per mL 200 mg/1.14 mL pen injection | $0.093 per tablet 2 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once